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| 药物、碘131和手术治疗对甲状腺功能亢进患者骨密度以及骨代谢指标的影响 |
| Effect of drugs，iodine 131，and surgery on bone mineral density and bone turnover markers in hyperthyroid patients |
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| DOI：10.3969/j.issn.1006.7108.2015.04.017 |
| 中文关键词: 甲状腺功能亢进 骨质疏松 药物治疗 碘131治疗 手术治疗 |
| 英文关键词:Hyperthyroidism Osteoporosis Drug therapy Radioiodine therapy Surgical therapy |
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| 中文摘要: |
| 目的 比较药物治疗、碘131治疗和手术治疗对甲状腺功能亢进患者骨密度以及骨代谢指标的影响。方法 186名女性甲状腺功能亢进患者参加了本次研究，根据病情和患者自愿原则，接受药物治疗、碘131治疗或者手术治疗。比较治疗前以及治疗2年后3组患者骨密度和骨代谢指标的变化。结果 3组患者治疗后较治疗前骨密度明显改善，骨代谢指标显著下降。而3组患者之间骨密度以及骨代谢指标无显著差别。结论 药物、碘131和手术治疗均能有效改善甲状腺功能亢进患者骨密度，纠正骨代谢紊乱。 |
| 英文摘要: |
| Objective To evaluate the impact of drug therapy，radioiodine therapy，and surgical therapy in bone mineral density and biochemical bone turnover markers in patients with hyperthyroidism. Methods A total of 186 female patients with hyperthyroidism were enrolled in the study. They received drug therapy，radioiodine therapy，or surgical therapy according to the disease course and their own wish. Bone mineral density and biochemical bone turnover markers were compared at the time of enrollment and after 2-year treatment. Results Bone mineral density increased and biochemical bone turnover markers decreased significantly in all patients in 3 groups. No difference between bone mineral density and bone turnover markers were found among the 3 groups. Conclusion Drug therapy，radioiodine therapy，and surgical therapy improve bone mineral density and decrease biochemical markers of bone turnover in hyperthyroid patients. |
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