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| 含锶羟基磷灰石对骨质疏松症大鼠的影响 |
| The effect of strontium-containing hydroxyapatite implants in osteoporotic rats |
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| DOI： |
| 中文关键词: 骨形成 羟基磷灰石 种植体 骨质疏松症 锶 |
| 英文关键词:Bone formation Hydroxyapatite Implant Osteoporosis Strontium |
| 基金项目:教育部博士点基金（新教师类）（20130181120090) |
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| 中文摘要: |
| 目的研究含锶羟基磷灰石对骨质疏松症大鼠的影响。方法制备羟基磷灰石（HA)和10%含锶羟基磷灰石（10% SrHA，即HA中Sr与Ca的摩尔比例为1：9)种植体，以扫描电镜(SEM)、能量色散X射线能谱仪(EDX)、X射线衍射(XRD)检 测材料表面形貌特征。实验中将20只雌性SD大鼠均行双侧卵巢切除术，12周后将所有动物随机平均分为两组，并分别在 大鼠右侧股骨远端植人羟基磷灰石(HA)种植体和10%含锶羟基磷灰石（10% SrHA)种植体。植人术后8周，收集标本行显 微CT( micro-CT)和组织学分析。结果实验所得数据采用SPSS17. 0软件进行统计学分析。在micro~CT检验的结果中，相比 于HA种植体组，10% SrHA种植体组的相对骨体积提高了 42. 6%，骨结合率提高了 47. 1%，平均骨小梁数量提高了 27. 3%， 平均骨小梁厚度提高了 31. 5%，平均骨小梁连接密度提高了 37. 4%，而平均骨小梁间距降低了 20. 1%。在组织学检验结果 中，10%SrHA组的相对骨面积密度提高了 47. 6%。结论以HA种植体作为对照，10% SrHA种植体可以提高骨密度和骨结 合率，同时改善种植体周的骨小梁微结构。 |
| 英文摘要: |
| Objective To study the effect of strontium-containing hydroxyapatite on osteoporotic rats. Methods Hydroxyapatite (HA) and 10% strontium containing hydroxyapatite (10% SrHA，the mole ratio of Sr and Ca 1:9) implants were prepared. Scanning electron microscopy (SEM)，energy dispersive microanalysis (EDX)，and X-ray diffraction (XRD) were used to study the surface feature of the implants. Twenty female SD rats were subjected to bilateral ovariectomy. After 12 weeks the animals were randomly divided into 2 groups of 10 rats each. HA or 10% SrHA were implanted in the right side of the distal femur in rats of each group respectively. 8 weeks after implantation，specimens for microscopic ( micro-CT) analysis and histology were collected. Results Statistical analysis was performed using SPSS17. 0 software. Micro-CT test results showed that compared to HA group， the relative bone volume increased by 42. 6%，the bone-to-implant contact increased by 47. 1%，the mean trabecular bone volume increased by 27. 3%，the mean trabecular thickness increased by 31. 5%，the mean trabecular connectivity density increased by 37. 4%，and the mean trabecular bone spacing reduced by 20. 1% in the 10% SrHA group. The bone area density in the 10% SrHA group increased by 47. 6% compared to HA group. Conclusion With HA implants as controls，10% SrHA implants increase the bone mineral density and bone-to-implant contact，and improve the trabecular bone micro structure around the implants. |
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