|
| 老年2型糖尿病与骨质疏松相关因素分析 |
| Analysis of osteoporosis related factors in the elderly with type 2 diabetes |
| |
| DOI： |
| 中文关键词: 老年 2型糖尿病；骨质疏松 维生素D |
| 英文关键词: |
| 基金项目:首都医学科研发展基金（2009 - 12 -2010 -2014 - 11) |
|
| 摘要点击次数: 1007 |
| 全文下载次数: 1090 |
| 中文摘要: |
| 目的通过对我科住院的118名老年2型糖尿病患者生化指标、骨密度(BMD)及维生素D水平的检测，分析探讨此类 患者骨质疏松的危险因素及与骨密度的相关关系。方法选取2011年3月至2012年6月在我院内分泌科住院的2型糖尿 病患者118例，男性55例，女性63例，年龄50 -89岁，平均年龄63.92 ± 9.26岁。所有人选女性均巳停经1年以上。空腹血 检测糖化血红蛋白、血糖、血钙、磷、生化及维生素D，双能X线骨密度测定。根据BMD分组：受检部位只要有一个或一个以上 的T值彡-2.5SD，或-2.5 SD -1.0 SD分别诊断为骨质疏松;骨量减少;骨量正常。根据25( OH) D 水平，>30 ng/ml为维生素D充足；>20 ng/ml且<30 ng/ml为不足；>10 ng/ml且<20 ng/ml为缺之，< 10 ng/ml为严重缺 乏。结果根据WHO骨质疏松诊断标准，本研究患者骨质疏松或骨量减少达到78%。骨质疏松组年龄显著大于骨量减少 及骨量正常组;体重指数(BMI)显著小于骨量减少及骨量正常组。三组之间FBS、HbA1c、血钙、磷、血脂及维生素D水平均无 统计学差异。维生素D不足占6. 9%，缺乏占73. 7%，严重缺乏占16. 9%。Pearsen和Spearman ’ s相关分析显示：腰椎丽D 与 BMI 呈正相关(r =0.345，P <0.01)，与 TC、LDL~c、HDL~c 呈负相关（r = -0.27，-0.20，-0.19，P <0.05)。股骨颈 BMD 与 年龄呈负相关(r = -0.24，P <0.01)。血钙、磷、FBS、HbA1c、甘油三脂与各部位骨密度均无相关性。维生素D水平与血钙呈 显著正相关(r = 0.415，尸<0.01)，与HbA1c呈负相关(r = -0.265，尸<0.01)。维生素D水平与各部位BMD均无相关性。结 论增龄及体重指数偏低，同样是老年2型糖尿病骨质疏松的重要危险因素;脂代谢及糖代谢紊乱对骨密度负面的影响作用 也应引起重视;维生素D缺乏在这一人群当中更加严重。 |
| 英文摘要: |
| Objective To determine the relationship between osteoporosis and bone mineral density (BMD) and the risk factors for osteoporosis by studying serum biochemical index in 118 elderly patients with type 2 diabetes in our department. Methods A total of 118 elderly patients with type 2 diabetes were randomly selected from March 2011 to June 2012 in the Department of Endocrinology in the hospital，including 55 males and 63 females，aging from 50 to 89 years old，with a mean age of 63. 92 士 9. 26 years. All the women were at least 1 year after menopause. Fasting blood sample were collected to determine glycosylated hemoglobin， blood sugar， blood biochemical parameters， vitamin D， calcium， phosphorus. BMD were determined using dual energy X^ay absorptiometry. According to BMD，osteoporosis group (T value ^ -2.5 SD)，osteopenia group ( -2. 5 SD < T ^ - 1.0 SD)， and normal bone mass group (T > -1.0 SD) were divided. According to the serum 25 ( OH) D level，sufficiency group ( >30 ng/ ml)，insufficiency group ( >20 ng/ml and <30 ng/ml)，deficiency group ( >10 ng/ml and - <20 ng/ml)，severe deficiency group (< 10ng/jml) were divided. Results ccording to the WHO criteria，in this study patients with osteoporosis or bone loss were up to 78%. The age of patients in the osteoporosis group was significantly older than that in the bone loss and the normal bone mass group; Body mass index (BMI) of in the osteoporosis group was significantly lower than that in the bone loss and bone mass normal group. Among the three groups，FBS，HbA1c，blood calcium，phosphorus，blood lipid，and vitamin D level were not statistically different. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |