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| Extract of Cornus officinalis SIEB ameliorates osteoporosis in Spinal Cord -Injured Rats |
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| DOI： |
| 中文关键词: 中医中药 动物实验 Cornus officinalis CO；脊髓损伤 大鼠 骨质疏松 |
| 英文关键词:Cornus officinalis Spine cord injury Rat Osteoporosis |
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| 中文摘要: |
| 目的观察山茱萸的提取物对脊髓损伤大鼠的骨质疏松的治疗作用。方法40只Wistar雄性大鼠分成四组:标准对 照组、脊髓损伤组、脊髓损伤高剂量提取物治疗组、脊髓损伤低剂量提取物治疗组。除标准对照组外，建立脊髓损伤引起的骨 质疏松大鼠模型，然后进行相关生物化学、骨密度及形态的分析和比较。结果与标准对照组相比，脊髓损伤组的大鼠显示 骨量、生物化学指标和形态学参数的显著下降。山茱萸提取物高剂量组治疗大鼠胫骨骨干内、外部区域骨质疏松显示剂量依 赖性。结论山茱萸提取物治疗可能通过剌激成骨细胞引骨组织反应，从而导致形态学的变化。 |
| 英文摘要: |
| This study investigated the effects of extract of Cornus officinalis CO) on bone loss in spinal cord-injured rats. Forty male Wistar rats were used to establish osteoporosis induced by spinal cord injury, subsequently divided into four groups: standard control group (CG) ； spinal cord-injured control (SC) ; spinal cord-injured treated with low-dose extract (L group) ； and spinal cord-injured treated with high-dose extract (H group). Biomechanical, densitometric, and morphometric analyses were performed. SC rats showed a significant decrease in bone mass, biomechanical properties, and morphometric parameters (versus CG). CO-treated rats showed significantly higher values of inner diameter and internal and external areas of tibia diaphysis in a dose-dependent manner. We conclude that the extract of Cornus officinalis SIEB et. ZUCC treatment was able to initiate a positive bone-tissue response, might through stimulation of osteoblasts, which was able to determine the observed morphometric modifications. |
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