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| 类风湿关节炎患者血清CEA，CA125水平与肿瘤相关性分析 |
| The correlation analysis between serum levels of CEA and CA125 and the tumor in patients with rheumatoid arthritis |
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| DOI：10.3969/j.issn.1006-7108.2015.06.003 |
| 中文关键词: 关节炎 类风湿 CEA CA125 DAS28评分 肿瘤 |
| 英文关键词:Arthritis Rheumatoid CEA CA125 DAS28 score Cancer |
| 基金项目:广西自然科学基金（2013GXNSFBA019181）；广西壮族自治区卫生厅自筹经费科研课题（Z2012425）；广西壮族自治区中医药民族医学自筹经费科研课题（gzzc1238） |
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| 中文摘要: |
| 目的 研究类风湿关节炎（rheumatoid arthritis，RA）患者血清肿瘤标记物水平与其病情活动度及肿瘤发生的相关性。方法 统计RA患者35例，健康对照个体31例，均进行血清肿瘤标志物CEA、CA125水平测定，并对RA组患者进行CRP、ESR测定及DAS28评分。对两组患者血清肿瘤标志物水平及阳性率进行比较，对RA组血清肿瘤标志物水平与CRP、ESR及DAS28评分进行相关性分析。对两组肿瘤阳性率进行比较。采用ι检验，χ2检验，Spearman相关系数进行统计学分析。结果 RA组患者血清CEA、CA125、水平及阳性率高于正常对照组（P＜0.05），其中血清CEA、CA125水平与ESR、CRP及DAS28评分呈正相关（P均＜0.05）。RA组患者肿瘤发生率与正常组无显著差别（P＞0.05）。结论 RA患者血清肿瘤标志物CEA及CA125水平及阳性率升高，与疾病活动有关，但肿瘤阳性率未升高，故血清CEA及CA125水平可作为评估RA患者疾病活动度的参考指标之一。 |
| 英文摘要: |
| Objective To identify the serum CEA and CA125 levels in rheumatoid arthritis (RA) patients and their association with the characteristics of the tumor. Methods Serum levels of CEA and CA125 in 35 RA patients and 31 healthy controls were detected. ESR and CRP were detected and the disease activity was assessed by DAS28 score in RA group. The difference of serum levels of CEA and CA125 between RA group and healthy control group was compared. The association between the serum CEA and CA125 levels and ESR, CRP, and DAS28 score was further revealed. The difference of the occurrence of cancers between RA group and healthy control group was compared. T test, χ2 test, and Spearman rank correlation were used for statistical analysis. Results Serum levels and positive rates of tumor markers CEA and CA125 were significantly increased in RA group compared to those in healthy control group (P<0.05). The serum levels of CEA and CA125 had a positive correlation with the levels of ESR, CRP, and DAS28 score in RA group (P<0.05). There was no significant difference in the occurrence of cancers between RA group and healthy control group (P<0.05). Conclusion The serum concentrations of CEA and CA125 in RA group increase significantly but the occurrence of cancers does not increase. The tumor markers CEA and CA125 may play a role in evaluating the disease activity of RA. |
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