中国骨质疏松杂志

莆田地区畲族的骨密度与骨生化指标以及睾酮雌二醇之间的关系

The relationship among bone mineral density，bone biochemical markers，testosterone and estradiol of Chinese She-zu in Putian

DOI：10.3969/j.issn.1006-7108.2015.06.013

中文关键词: 骨密度汉族畲族 25-羟基维生素D3 骨钙素雌二醇睾酮甲状旁腺激素 1型前胶原氨基末端肽碱性磷酸酶

英文关键词:Bone mineral density Han-zu She-zu 25-hydroxy vitamin D3 Bone Gla protein Estradiol Testosterone Parathyroid hormone Type 1 procollagen aminoterminal peptide Alkaline phosphatase

基金项目:民政部十一五期间老年学研究骨质疏松项目（民人科教字 [2008]47-1-44）；2012年莆田市医学科技计划资助项目（2012S01(1)）；2012年福建省医学创新课题资助项目（2012-CXB-46）；2014年福建省自然科学基金资助项目（2014J01391）

作者	单位
王国荣杨俊华郑逊杨季萍周芳烨	福建医科大学附属莆田市第一医院，福建莆田 351100

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中文摘要:

目的探讨莆田地区畲族健康人群骨密度与骨生化指标、睾酮以及雌二醇之间的关系，并与汉族人群比较，为本地区骨质疏松防治提供依据。方法选择本地区畲族聚集地40岁以上健康成年人，其中畲族532人，汉族563人，应用美国Osteometer Medi Tech公司生产的DTX-200骨密度吸收仪检测骨密度，以及用罗氏公司的骨生化指标仪器及试剂盒，测量骨密度以及25羟维生素D（25（OH）D3）、骨钙素（BGP）、雌二醇（E2）、睾酮（T）、甲状旁腺激素（PTH）、1型前胶原氨基末端肽（P1NP）、碱性磷酸酶（ALP）。把上述检测的数据结果输入电脑，应用SPSS17.0软件包进行数据分析。结果不管畲族和汉族的骨密度均随着年龄的增大而下降，同年龄段男性均高于女性。畲族女性除在40～49岁年龄段稍高于汉族外，其他年龄组汉族女性均高于畲族。而畲族男性在60～69岁年龄段稍高于汉族男性，其他年龄组汉族男性均高于畲族，但汉族与畲族间都没有显著性差异（P>0.05）。汉族的25(OH)D3明显高于畲族，尤其女性在40～60岁年龄段、男性在50～69岁年龄段为正相关（P<0.05）；汉族的BGP高于畲族(P<0.05)，汉族男的E2指标均高于畲族男，且40～59年龄段尤为明显（P<0.05）。P1NP在汉族男女性高于畲族男女性（P<0.05）。经皮尔森相关分析，骨密度与E2、25OHD3、T成正相关，而与PTH、BGP、ALP成负相关,与ALP无相关。结论本研究25（OH）D3、BGP、P1NP、E2测定可以作为汉族、畲族健康人群早期检测指标，畲族的25（OH）D3水平普遍偏低，可能与他们的生活方式或者维生素D基因有关，值得进一步研究。骨密度与25（OH）D3、E2、T有明显正相关，而与PTH、PINP、BCG负相关，与ALP无明显相关。

英文摘要:

Objective To explore the relationship of bone mineral density (BMD) with bone biochemical markers and testosterone and estradiol of Chinese She-zu in Putian, and compare with the Han-zu, in order to provide the basis for prevention and treatment of osteoporosis in this region. Methods The healthy adults over 40 years old of Chinese She-zu from the gathering place, including the Chinese She-zu 532 and Chinese Han 563 were selected. By DTX-200 BMD absorptiometry, the BMD were detected. BMD,25（OH）D3,BGP,E2,T,PTH,P1NP and ALP were measured. The date were analyzed with SPSS17.0 software. Results The BMD of She-zu or Han-zu decreased with age, the BMD of men were higher than women in same age. The BMD of women of Han-zu were higher than She-zu in same age except the age of 40～49, the BMD of men of Han-zu were higher than She-zu in same age apart from the age of 60～69.There were no significant differences between Han-zu and She-zu（P<0.05）. BMD were positively correlated with E2, 25（OH）D3 and T ,and were negatively correlated with BGP, ALP . 25（OH）D3 of Han-zu were significantly higher than She-zu, especially women in the 40～60 age and men in the 50～69 age. BGP of Han were higher than She-zu (P <0.05), The E2 of Han male were higher than She-zu male , especially 40～59 age group (P <0.05). P1NP of Han were higher than She-zu (P <0.05). The Pearson correlation analysis showed that BMD were positively correlated with E2,25OHD3 and T, and negatively correlatied with PTH, BGP, ALP. Conclusions The study of 25（OH）D3, BGP, P1NP, E2 can be used as early detection targets for the Han-zu, She-zu healthy people, 25 (OH) D3 levels of She-zu generally are low, this may be related to their lifestyle or vitamin D gene. BMD are positively correlated with 25 (OH) D3,E2 and T significantly, negatively correlated with PTH, PINP, BCG, and not correlated with ALP.

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