中国骨质疏松杂志

喝牛奶与绝经后妇女骨密度关系的临床研究

Study of the relationship between milk drinking and bone mineral density in postmenopausal women

DOI：10.3969/j.issn.1006-7108.2015.06.019

英文关键词:Milk drinking Bone mineral density Postmenopausal women

基金项目:国家自然科学基金资助项目（81173280，30672703）

作者	单位
胡智旭1 范超领1谢丽华2 李生强2 陈娟2 许惠娟2 葛继荣1,2*	1．福建中医药大学骨伤学院，福州 350122 2．福建省中医药研究院，福州 350003

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中文摘要:

目的探讨喝牛奶与绝经后妇女骨密度的相关性。方法随机选择1478例福州汉族绝经后妇女，喝牛奶组795例，不喝牛奶组683例，双能X线骨密度仪测定腰椎、股骨颈、大转子和Ward区骨密度，SPSS 18.0统计软件分析喝牛奶与不同部位骨密度的关系。结果 ①喝牛奶组与不喝牛奶组两组比较，结果为年龄、体重、质量指数有差异。②腰椎骨密度与年龄、体重指数、喝牛奶、体重进行逐步回归分析（y=0.843-0.003×年龄-0.010×BMI+0.006×体重+0.016×喝牛奶，β=0.392,回归系数t检验P=0.000）,体重对腰椎骨密度影响较大。③体重、体重指数、年龄为协变量，喝牛奶为变量，行协方差分析，喝牛奶组腰椎BMD（0.754±0.138g/cm2）明显高于不喝牛奶组（0.742±0.113g/cm2），统计学有显著性差异(F=5.935，P=0.015)，股骨颈骨密度无差异。④喝牛奶组骨质疏松患病率为69.18%，不喝牛奶组患病率为71.16%，两者比较无差异（P=0.42）。结论喝牛奶可维持绝经后女性腰椎高骨密度，这类人群适量饮用牛奶，一定程度上，具有预防骨质疏松的作用。

英文摘要:

Objective To investigate the correlation between milk drinking and bone mineral density in postmenopausal women. Methods A total of 1478 postmenopausal Han women living in Fuzhou were randomly selected, including 795 cases in milk drinking group and 683 cases in non-milk drinking group. BMD of the lumbar vertebrae, femoral neck, trochanter, and Ward，s area were measured using dual-energy X-ray absorptiometry. The correlation between BMD in different parts and milk drinking was analyzed using a SPSS 18.0 statistical software. Results (1) There were differences between milk drinking group and non-milk drinking group in age, weight, and BMI. (2) In the stepwise regression analysis between lumbar spine BMD and age, BMI, milk drinking, weight (y=0.843-0.003×age-0.010×BMI+0.006×wight+0.016×milk drinking, β=0.392, the regression coefficient t test, P=0.000), weight affected BMD of lumbar vertebrae in a larger extent. (3) When weight, BMI, and age were as covariate, milk drinking as variables for analysis of covariance, there were difference between the BMD of the lumbar vertebrae in milk drinking group (0.754±0.138g/cm2) and non-milk drinking group (0.742±0.113g/cm2, F=5.935, P=0.015). No difference was found in BMD of the femur. (4) The incidence of osteoporosis in milk drinking group was 69.18%, and in non-milk drinking group was 71.16%. No difference between the two groups was found. Conclusion Milk drinking is beneficial in maintaining high bone mineral density of the lumbar spine in postmenopausal women and can prevent osteoporosis to some extent.

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