中国骨质疏松杂志

破骨细胞分化过程中的信号通路及信号因子的研究进展

Research advance in signal pathways and signal factors during the process of osteoclast differentiation

DOI：10.3969/j.issn.1006-7108.2015.06.025

英文关键词:Osteoclast differentiation Signal pathway Signal factors

基金项目:辽宁省科学技术计划项目（2013225049）

作者	单位
王链链郭晓英*	中国医科大学临床医学七年制，沈阳110001

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中文摘要:

破骨细胞（osteoclast，OC）来源于骨髓，在生长发育过程中，起着骨吸收的重要功能，其增多或减少会引起骨质疏松或骨质硬化等相关的骨代谢性疾病。本文将从OC分化过程中所涉及的信号通路（NF-κB、Src-PI3K-Akt、MAPK、CN/NFAT、IDO/Tryptophan通路等）及相关信号因子（PU 1、 Lhx2、TNF-α、 M-CSF、TGF-β等）方面，对OC分化的信号通路及相关信号因子的研究进展进行简要综述，以期能为相关骨代谢性疾病的治疗提供新的思路。

英文摘要:

The osteoclast is derived from bone marrow. During the growth and developmental process, it plays an important role in bone resorption. An increase or decrease of the osteoclast may cause osteoporosis or bone sclerosis, and other bone metabolic diseases. This review focuses on the advances in signal pathways (such as NF-κB pathway, Src-PI3K-Akt pathway, MAPK pathway, CN/NFAT pathway, IDO/Tryptophan pathway, etc.) and signal factors (such as PU.1, Lhx2, TNF-α, M-CSF, TGF-β, etc.) during the process of osteoclast differentiation, in order to provide new ideas for the treatment of bone metabolic diseases.

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