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| 体检人群脂肪性肝病前臂桡骨远端双能X线骨密度分析研究 |
| Analysis of bone mineral density of the distal forearm with dual energy X-ray for people with fatty liver disease |
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| DOI：10.3969/j.issn.1006.7108.2015.07.017 |
| 中文关键词: 脂肪肝 骨密度 骨质疏松 身高体重指数 肥胖 |
| 英文关键词:Fatty liver BMD Osteoporosis Body mass index Obesity |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨脂肪肝与骨密度间的变化规律及关系。方法 选自2013年在我院进行B超检查和骨密度测量的体检人群，共计1014例。以B超诊断脂肪肝为标准：脂肪肝组469例，男性370例、女性99例;非脂肪肝组545例，男性282例、女性 263例。以BMI>25kg/m2及BMI <25 kg/m2为标准：肥胖组465例、男345例、女120例;非肥胖组549例，男307例、女242 例。年龄20 ~85岁，平均49. 8岁。按男、女性别，每十岁年龄段分为脂肪肝和非脂肪肝组、肥胖组和非肥胖组，分别计算各组、各年龄段骨密度和BMI。利用SPSS19. 0统计软件对数据进行处理分析，计量资料采用 方式表示，两变量间相关性采 用Pearson乘积-距相关分析，两组数据之间比较用独立样本T检验，P <0. 05为差异有统计学意义。结果 男性40-60岁， 女性40 -70岁脂肪肝组BMD高于非脂肪肝组BMD(P <0.05)，脂肪肝组的骨量丢失低于非脂肪肝组;男性20 -70、女性30 -70脂肪肝组BMI高于非脂肪肝组BMI(P < 0. 05)，由Pearson乘积-距相关分析，P <0. 0001，脂肪肝与肥胖之间存在的直线相关关系具有统计学意义，两者正相关;男性20 -60岁，女性40、50、70岁年龄段肥胖组BMD高于非肥胖组(P < 0. 05)，肥胖组的骨量丢失低于非肥胖组;各组男女峰值骨量在30岁年龄段，40岁开始丢失，男性肥胖组峰值骨量高于非肥胖组(P < 0.05)。有统计学意义的男女各年龄段，脂肪肝组和肥胖组骨量减低发病率明显低于非脂肪肝组和非肥胖组。脂肪肝组和肥胖组发病率接近，非脂肪肝组和非肥胖组的发病率接近。结论 脂肪肝与骨密度间可能通过BMI存在一定的影响关系，BMI 对脂肪肝的影响明确，对骨密度的影响尚不明确，可能存在阈值，有必要进一步深人研究。 |
| 英文摘要: |
| Objective To investigate the changes and relationship between fatty liver and bone mineral density. Methods A total of 1014 healthy screen people who had B-ultrasound examination and BMD measurement in our hospital in 2013 were selected. According to B-ultrasound standard of fatty liver，469 cases were divided to fatty liver group，including 370 males and 99 females，and 549 cases were divided to non-fatty liver group，including 307 males and 242 females. According to BMI，465 cases were divided to obese group (BMI≥25 kg/m2)，including 345 males and 120 females，and 549 cases were divided to non-obese group (BMI <25 kg/m2)，including 307 males and 242 females. They were 20 - 85 years old，with an average of 49. 8 years old. Fatty liver and non-fatty liver group，obese and non-obese group were divided by gender and every 10-year-old of age. BMD and BMI of each group were calculated. Data were processed and analyzed with SPSS 19. 0 software. The measurement data were represented as . The correlation between the two variables was performed using Pearson correlation analysis. Data between the two groups were compared with independent sample t-test，and P< 0. 05 represented the difference was statistically significant. Results The BMD in fatty liver was higher than that in non-fatty liver group of 40 - 60 - year-old males and 40 - 70 - year-old females (P < 0.05)，and the boss lose in fatty liver was lower than that in non-fatty liver group. BMI in fatty liver was higher than that in non?-fatty liver group of 20 - 70 - year-old males and 30 - 70 - year-old females (P< 0. 05). Pearson correlation analysis showed that fatty liver was positively and linearly correlated with obesity (P <0. 0001) . with statistical significance. BMD in obese group was higher than that in non-obese group of 20 - 60 - year-old males and 40 - , 50 - , and 70 - year-old females. The boss lose in obese group was lower than that in non-obese group. The peak bone mass in each group of males and females appeared in 30 - year group,and it began to lose on 40 years old. The peak bone mass of males in obese group was higher than that in non-obese group (P < 0. 05). The incidence of osteopenia was significant lower in fatty liver group and obese group than that in non-fatty liver group and in non-obese group. The incidence in fatty liver group was close to that in obese group, and it was close in non-fatty liver group and in non-obese group. Conclusion Fatty liver may affect BMD through BMI. The effect of BMI on fatty liver was clear, but the effect on BMD is not clear. There may be a threshold existing. It is necessary to study further. |
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