|
| 关注系统性红斑狼疮继发性骨质疏松 |
| Pay attention to the secondary osteoporosis in systemic lupus erythematosus |
| |
| DOI：10.3969/j.issn.1006.7108.2015.07.027 |
| 中文关键词: 系统性红斑狼疮 骨质疏松 发病机制 |
| 英文关键词:Systemic lupus erythematosus Osteoporosis Pathogensis |
| 基金项目:河北省科技厅科研计划项目（12277731) |
|
| 摘要点击次数: 640 |
| 全文下载次数: 534 |
| 中文摘要: |
| 系统性红斑狼疮（systemic lupus erythematosus,SLE)是多系统损害的自身免疫性疾病，糖皮质激素和免疫抑制剂是治疗的主要药物。SLE的骨损害包括骨量减少、骨质疏松(osteoporosis. OP)、无菌性骨坏死和骨折，随着SLE生存期的延长，心血管并发症和OP成为影响患者生活质量和生存的主要因素,同时OP对于心血管的发病也有促进作用,是目前备受关注的并发症。OP是一种以骨量减少和骨组织的细微结构破坏为特征的全身性疾病。关于SLE的骨质疏松也存在不少争议,主要集中在OP的发病率和骨质疏松与激素治疗关系两个方面。就OP发病率来讲，不同的研究得出的结论不同。SLE的骨质疏松涉及多种机制包括炎性因素、免疫介导的因素、固有因素、代谢因素、药物因素和疾病本身的因素。SLE相关的骨质疏松的治疗首先是治疗原发病，此外健康的生活方式包括钙剂和维生素D的补充也非常重要，对诊断骨质疏松的SLE患者应及时给予双膦酸盐治疗。 |
| 英文摘要: |
| Systemic lupus erythematosus (SLE) is an autoimmune disease involving multisystem. Glucocorticoids and immune- suppressors are main drugs for the treatment. The bone damage of SLE includes osteopenia, osteoporosis ( OP), aseptic osteonecrosis, and fractures. In recent years the survival of patients with SLE has increased markedly,and the complications of cardiovascular disease and OP become major factors affecting quality of life and death of the patients. OP can promote the onset of cardio-vascular disease,and it is the complication that we pay attention to. OP is a systemic disease characterized by bone loss and disruption of the microstructure. There are some debates about OP in SLE, mainly focusing on the incidence of OP and the relationship between OP and steroid treatment. For the incidence of OP, the conclusion is different from different study. The pathogenesis of OP in SLE includes chronic inflammation, immunological factors, traditional factors, metabolism factors, drug factors, and disease itself. Optimal treatment of the underlying SLE is the first step toward prevention of OP and fractures. Apart from that, a healthy lifestyle is important such as calcium and vitamin D supplementation. Bisphosphonates should be timely given for the SLE patients with osteoporosis. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|