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| 2型糖尿病性骨质疏松动物模型建立 |
| Establishment of the osteoporosis model in animals with type 2 diabetes |
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| DOI：10.3969/j.issn.1006.7108.2015.07.028 |
| 中文关键词: 2型糖尿病；骨质疏松 大鼠 动物模型；骨代谢 |
| 英文关键词:Type 2 diabetes mellitus Osteoporosis Rat Animal model Bone metabolism |
| 基金项目:2011年国家自然科学基金（81160486);广西名老中医民族医传承工作室建设项目桂卫中[2014]9号文件 |
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| 中文摘要: |
| 2型糖尿病是在环境因素、遗传因素等共同作用下所致的以胰岛素抵抗为主，可伴有胰岛素分泌不足，表现为慢性血糖升高的代谢性疾病。2型糖尿病所致骨质疏松或骨代谢异常目前机制尚不明确，研究2型糖尿病性骨质疏松发病机制及其防治的关键之一是复制理想的动物模型，国内以药物链脲佐菌素注射大鼠造模观察骨代谢异常文献较多，亦可见自发性2型糖尿病大鼠或小鼠所致骨量降低等文献报道。在造模过程中饲料喂养、药物注射剂量、观察指标等是影响2型糖尿病造模成功的因素，而大鼠成模的血糖标准未有统一定论，根据在以大鼠或小鼠造模过程中所遇到的常见问题，本文从最新国内外文献在2型糖尿病继发骨质疏松或骨代谢异常大鼠或小鼠造模方面有关的动物选择、造模方法、成模标准及时间等问题作一综述。 |
| 英文摘要: |
| Type 2 diabetes is a metabolic disease manifested as chronic hyperglycemia，mainly due to insulin resistance，and it may be associated with lack of insulin secretion，which is the result of environmental factors and genetic factors. The mechanism of type 2 diabetes-induced osteoporosis or disorder of bone metabolism is unclear at present. One of the keys to research the pathogenesis and the prevention of type 2 diabetic osteoporosis is to create an ideal animal model. The national literatures about observing bone metabolism are more in streptozotocin injected rats model. Spontaneous osteopenia in type 2 diabetes mellitus rats has also been reported in some literatures. In the modeling process，diet，medication dose，observing indicators and so on are the successful factors of type 2 diabetes model. But there is no consensus in the rat glucose level. According to the common problems encountered in the process of rat modeling，this paper reviews animal selection，ways，and standard and time in the animal model of type 2 diabetic osteoporosis from the latest literatures. |
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