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| 唑来膦酸抑制骨质疏松骨髓脂肪增多 |
| A single dose of zoledronic acid reverses the marrow adiposity of estrogen deficiency-induced osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2015.08.004 |
| 中文关键词: 骨质疏松 骨密度 骨髓脂肪 水脂分离 |
| 英文关键词:Osteoporosis Bone mineral density Marrow fat Water-fat separation |
| 基金项目:国家自然科学基金项目（81202809);上海市闵行区卫生局资助（2013MW71) |
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| 中文摘要: |
| 目的 探讨唑来膦酸干预原发性骨质疏松（OP)模型鼠后骨髓脂肪含量变化规律。方法 27只3月龄雌性SD大鼠随机均分为假手术组(SHAM)、去卵巢组(OVX)及OVX +唑来膦酸干预组(ZOL)。分别在术后0、6、12周行MRI水-脂分离成像及BMD扫描，获取骨髓脂肪分数(MFF)及BMD。实验结束行骨髓脂肪细胞定量分析。结果 OVX组MFF呈时序性增高而BMD呈时序性降低。第6、12周时，OVX组MFF较基线时分别增高40. 0%、69. 4%(P <0. 001)。第6周始组间MFF有显著性差异，而组间BMD至第12周时才有统计学差异(P <0. 001)。OVX组骨髓脂肪细胞密度、直径及面积百分比较SHAM组分别增高57 3%、29. 5%、163%，较ZOL分别增高65%、22. 2%、144% (P <0. 001)。ZOL组MFF及脂肪细胞定量参数与SHAM 组无明显差异。结论 ZOL保护骨受损同时，可能通过抑制骨髓脂肪含量而起作用。 |
| 英文摘要: |
| Objective To explore the effect of zoledronic acid (ZA) in restoring marrow adipogenesis in estrogen-deficient rats. Methods Twenty-seven female SD rats were randomly divided equally into SHAM，ovariectomized (OVX)，and OVX + ZOL groups. Marrow fat fraction (MFF) and bone mineral density (BMD) were measured at 0，6，and 12 weeks. Marrow adipocytes were quantitatively evaluated by histopathology. Results OVX rats exhibited time-depend increase in MFF but decrease in BMD. The increase of MFF above baseline was 40. 0% at week 6 and 69. 4% at week 12，respectively (P < 0. 001). Compared with SHAM rats，MFF in OVX rats markedly elevated at week 6 but a reduction in BMD was first detected at week 12 (P <0. 001). The adipocyte density，diameter，and volume in OVX rats increased by 57. 3%，29. 5%，and 163%，respectively，compared with those in SHAM rats，and by 65%，22. 2%，and 144%，respectively，compared with those in ZOL rats (P <0. 001). MFF and adipocyte parameters were not different between ZOL rats and SHAM rats. Conclusion A single dose of ZOL is able to reverse the marrow adiposity of OVX-induced osteoporosis. |
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