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| 仙灵骨葆胶囊治疗骨质疏松症的疗效及其对骨代谢及骨转换指标的影响分析 |
| Analysis of the efficacy of Xianlinggubao capsule on the treatment of osteoporosis and its influences in the markers of bone metabolism and bone turnover |
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| DOI：10.3969/j.issn.1006.7108.2015.09.007 |
| 中文关键词: 骨质疏松 仙灵骨葆胶囊 骨矿密度 骨代谢 骨代谢 |
| 英文关键词:Osteoporosis Xianlinggubao capsule Bone mineral density Bone metabolism Bone turnover |
| 基金项目:贵州省中医药管理局中医药、民族医药科学技术研究课题（QZYY2013-116) |
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| 中文摘要: |
| 目的 分析仙灵骨葆胶囊治疗骨质疏松症的疗效及其对骨代谢及骨转换指标的影响。方法 将160例原发性骨质疏松症(POP)患者分为观察组80例和对照组80例。对照组患者行钙尔奇D联合唑来膦酸盐治疗，观察组患者行仙灵骨葆胶囊治疗。于2组患者治疗前、治疗3疗程后及6个疗程后，测量患者的腰椎正位(L2-4)和右股骨颈的骨密度（BMD)，并检测患者的骨代谢指标包括血钙(Ca)、磷(P)、碱性磷酸酶(ALP)及骨转换指标包括骨钙素（OC)和I型胶原交联C-末端肽（CTX-1)。 同时，分析BMD与OC、CTX-1的相关性。结果 治疗后，2组患者的BMD较治疗前均增加(P均<0.05)，但治疗6个疗程后，观察组患者BMD的增加幅度大于对照组(P <0. 05)。治疗后，2组患者的OC均较治疗前上升（P均<0. 05)、CTX-1均较治疗前下降(P均<0. 05);但治疗6个疗程后，观察组患者OC、CTX-1的改善幅度均大于对照组（P均< 0. 05)。BMD与OC呈正相关性(r = 0.352，P =0.21)，与CTX-1呈负相关性(r = -0.453，P =0.017)。结论 仙灵骨葆胶囊治疗骨质疏松症的疗效 显著，能有效增加患者的骨密度，改善骨代谢及骨转换状态，控制骨量减少；且OC、CTX-1与患者BMD密切相关，可作为评价 POP疗效的有效指标。 |
| 英文摘要: |
| Objective To analyze the effect of Xianlinggubao capsule on the treatment of osteoporosis and its influence in the markers of bone metabolism and bone turnover. Methods One hundred and sixty patients with primary osteoporosis (POP) were divided into the observation group (80 cases) and the control group (80 cases). The patients in control group received Caltrate D and zoledronic acid. The patients in observation group received Xianlinggubao capsule. Bone mineral density (BMD) of the lumbar spine (L2-4) and the right femoral neck was measured before and after 3-and 6-course of the treatment. Bone metabolic indexes including blood calcium (Ca)，phosphorus ( P)， alkaline phosphatase ( ALP)，and bone turnover index including osteocalcin (OC) and type I collagen cross-linking C-peptide (CTX) were detected. The correlation between BMD，OC，and CTX-1 was analyzed. Result After the treatment，BMD increased in both 2 groups (P <0.05). After 6-course of treatment，BMD in patients of observation group increased more than that in patients of control group (P < 0. 05). After the treatment，OC increased but CTX-1 decreased in both 2 groups (P < 0. 05). After 6-course of treatment，the changes of OC and CTX-1 were greater in the observation group than those in the control group (P < 0. 05). BMD was positively correlated with OC ( r = 0. 352，P = 0. 352)， but was negatively correlated with CTX-1 ( r = 0. 453，P = 0. 453). Conclusion The effect of Xianlinggubao capsule on the treatment of osteoporosis t is distinct. Xianlinggubao capsule effectively increases BMD of the patients ，improves bone metabolism and bone turnover status，controls bone loss. OC and CTX - 1 are closely correlated with BMD. They can be used as effective indexes for evaluating the treatment of POP . |
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