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| 绝经后女性骨密度与脂代谢相关性研究 |
| Relationship between BMD and lipid metabolism in postmenopausal women |
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| DOI：10.3969/j.issn.1006.7108.2015.11.011 |
| 中文关键词: 绝经后女性 骨密度 血脂 |
| 英文关键词:Postmenopausal women BMD Blood lipid |
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| 中文摘要: |
| 目的 分析绝经后女性骨密度（BMD)与脂代谢相关性，探讨血脂紊乱对BMD的影响。方法 选择509名自然绝经后女性，未患有影响骨代谢疾病,无长期服用影响骨代谢的药物史，未使用过调脂药物。根据年龄段不同，分为<60岁、60~69 岁、70 ~79岁、>80岁4组，分别测量身高、体重、总胆固醇（TC)、甘油三酯（TG)、低密度脂蛋白胆固醇（LDL-C)和高密度脂蛋白胆固醇（HDL-C),并采用双能X线吸收测定仪测量正位腰椎，左侧股骨颈（Neck)处BMD,采用直线相关分析法分析 BMD和血脂之间的相关性，并控制年龄、体重指数因素后进行偏相关分析。结果 不同年龄组BMD、TC、LDL-C有显著差异。 各年龄组BMD与TC及LDL-C呈负相关，与HDL-C呈正相关，与TG无相关性。校正年龄、体重指数后的偏相关显示BMD仍与TC及LDL-C呈负相关，与HDL-C呈正相关。结论 绝经后女性TC和LDL-C升高与BMD下降密切相关，是骨质疏松的重要影响因素。 |
| 英文摘要: |
| Objective To analyze the correlation between BMD and lipid metabolism in postmenopausal women and to explore the effect of dyslipidemia on BMD, Methods Five hundred and nine postmenopausal women, who did not suffer from any diseases that affect bone metabolism, and did not use drugs that affect lipid metabolism, were selected. According to thir age, they were divided into 4 groups, <60，60-69, 70-79，and ≥80. Height, weight, TC, TG, LDL-C, and HDL-C were determined. BMD of lumbar vertebrae 1 -4 (L1-4) and the neck of femur (Neck) was measured using dual energy X-ray absorptiometry. The correlation between BMD and blood lipids was analyzed with the linear correlation analysis and the partial correlation analysis after control of age and BMI. Results BMD, TC, and LDL-C were significantly different among the different age groups. BMD in each age group was negatively correlated with TC and LDL-C, but positively correlated with HDL-C and without correlation with TG. Partial correlation analysis after control of age and body mass index showed that BMD was still negatively correlated with TC and LDL-C and positively correlated with HDL-C. Conclusion The increase of TC and LDL-C in postmenopausal women is closely related to the decrease of BMD, which is an important influential factor in osteoporosis. |
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