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| 240例绝经后髋部脆性骨折患者血清铁蛋白与维生素D水平的相关性研究 |
| Relationship between serum ferritin and vitamin D in 240 postmenopausal women with fragile hip fractures |
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| DOI：10.3969/j.issn.1006.7108.2015.11.016 |
| 中文关键词: 绝经后骨质疏松；血清铁蛋白；铁蓄积 维生素D |
| 英文关键词:Postmenopausal osteoporosis Ferritin Iron accumulation Vitamin D |
| 基金项目:江苏省妇幼健康科研项目（F201504）,国家自然科学基金（81273090），江苏省自然科学基金（BK2012608）,江苏省临床医学科技专项（BL2012004）,镇江市科技计划项目（SH2014031） |
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| 中文摘要: |
| 目的 研究绝经后髋部脆性骨折患者血清铁蛋白与维生素D的相互关系，探讨铁蓄积对绝经后髋部脆性骨折患者骨代谢的影响。方法 分析240例绝经后髋部脆性骨折患者资料，患者均检测血清铁蛋白（Fer)、25(OH)D3、骨转换及生化指标。按每10岁为1个年龄组，方差分析统计各组血清Fer、25(OH)D3和骨转换指标随年龄变化情况；按血清铁蛋白水平分组,t检验分析Fer正常组和Fer升高组25(OH)D3和骨转换指标的差异;Pearson线性相关分析和偏相关分析明确血清Fer与 25(OH)D3的相关性。结果 患者血清Fer普遍升高，而且随增龄而增加，25(OH)D3普遍降低，随增龄而下降（P <0.05);血清Fer升高组血清25(OH)D3水平明显低于Fer正常组（P<0. 05);血清Fer和25(OH)D3水平存在负相关（r= -0,22，P =0.001）,矫正年龄因素，二者仍然负相关（r= -0.19,P= 0.004);血清Fer与骨转换指标无明显相关性。结论 绝经后脆性骨折患者存在铁蓄积和低维生素D状态,二者存在负相关。该结果为铁蓄积与绝经后骨质疏松研究提供了新的临床证据。 |
| 英文摘要: |
| Objective To explore the effect of iron accumulation on bone metabolism in postmenopausal women with fragile fractures by analyzing the relationship between serum ferritin and vitamin D. Methods Serum ferritin, 25 ( OH ) D3, bone turnover, and biochemical indicators in 240 postmenopausal women with fragile fractures were detected. The subjects were divided into groups according to a 10-year division and the level of ferritin, respectively. Variance analysis was used to evaluate the change of serum ferritin, 25(OH)D3，and bone turnover indicators with age. Student t test was used to evaluate the difference of 25(OH) D3 and bone turnover indicators between ferritin normal and elevation groups. Pearson and partial correlation was used to evaluate the correlation among ferritin, 25 (OH) D3，and bone turnover indicators. Results The elevation of serum ferritin and insufficiency of 25(OH)D3 were prevalent among subjects, and ferritin increased and 25(OH)D3 decreased along with the increase of age (P<0. 05). The serum 25(OH)D3 was significantly lower in the group of ferritin elevation than in normal ferritin group (P <0. 05). The serum ferritin was negatively correlated with 25 (OH) D3 (r = - 0. 22, P = 0. 001). The negative correlation still existed after age adjustment (r = - 0. 19, P =0.004). No significant relationship was found between ferritin and bone turnover indicators. Conclusion Iron accumulation and vitamin D insufficiency are prevalent in postmenopausal women with fragile fractures. The results provide new clinical evidence for studying iron accumulation and postmenopausal osteoporosis. |
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