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| 干扰素与骨质疏松关系的研究进展 |
| Research progress in the relationship between interferons and osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2015.11.023 |
| 中文关键词: 干扰素 骨质疏松 骨免疫学 |
| 英文关键词:Interferons Osteoporosis Osteoimmunology |
| 基金项目: |
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| 中文摘要: |
| 近些年来骨骼系统与免疫系统的相互作用关系引起了人们的兴趣。作为免疫调节因子中的重要成员，干扰素同样对骨形成和骨吸收有着重大影响。目前发现与骨质疏松相关的干扰素主要包括IFN-α、IFN-β以及IFN-γ，本文对干扰素在骨质疏松形成过程中发挥的作用做了详细阐述，以期为骨质疏松症的防治提供新的思路。目前干扰素与骨质疏松关系的相关研究取得了较大的进步，在临床试验中，干扰素对部分继发骨质疏松症患者的治疗效果令人满意，想要把研究结果转化为临床仍 是一条较漫长的道路。干扰素的应用仍存在很多问题，这些问题如果得到妥善解决，将有助于将干扰素顺利应用于临床，也必将促使骨质疏松的防治水平进一步提高。 |
| 英文摘要: |
| The interaction between the immune and skeletal systems has drawn much attention in recent years. As important regulators of the immune family, interferons (IFNs) also interfere with bone formation and/or bone resorption. It has been found that osteoporosis-related IFNs include IFN-α, IFN-β, and IFN-γ. This article reviews the important role of IFNs in the development of osteoporosis, aiming at providing a new strategy in the prevention and treatment of osteoporosis. Currently large progress has been made in the research of the relationship between IFNs and osteoporosis. In clinical trials, the efficacy of IFNs is satisfied in part of secondary osteoporosis patients. It is still a long way to make transformation from research to clinic. Lot of problems exist in the application of IFNs. Solving the problems may help the clinical treatment. |
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