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| 2型糖尿病人群中应用FRAX评价骨折风险的研究 |
| Assessment of fracture risk with the FRAX score in patients with type 2 diabetes |
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| DOI：10.3969/j.issn.1006.7108.2015.12.013 |
| 中文关键词: 骨质疏松 骨折风险预测简易工具 糖尿病 |
| 英文关键词:Osteoporotic Fracture risk assessment tool Diabetes mellitus |
| 基金项目:江苏省科技支撑计划（社会发展）项目（BE2011605) |
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| 中文摘要: |
| 目的 探讨骨折风险预测简易工具（fracture risk assessment tool，FRAX)评分在2型糖尿病患者中骨折风险评估的应用。方法 选取278例糖尿病人群（糖尿病组）以及正常对照人群（对照组）504例，并收集相关临床指标。研究2型糖尿病患者中FRAX与糖尿病相关临床危险因素及其并发症之间的关系。结果 糖尿病组股骨颈、Ll、3、4的骨密度高于对照组，而糖尿病组中10年主要骨质疏松性骨折发生概率和10年髋部骨折发生概率低于对照组。多重线性回归中提示糖尿病患者中 FRAX评分与糖化血红蛋白、低血糖发生有相关性。结论 糖尿病应作为FRAX评分工具中的独立危险因素，以便建立更加精确预测糖尿病人群骨折发生风险的评分模型公式。 |
| 英文摘要: |
| Objective To evaluate the application of fracture risk assessment tool (FRAX) in patients with type 2 diabetes. Methods Clinical information of 278 patients with type 2 diabetes (DM group) and 504 normal-controls (NC group) was collected. The relationship between clinical risk factors and complication of diabetes and FRAX score was assessed in patients with diabetes. Results The bone mineral density at femur neck (FN) and the lumbar spine (L1，3, and 4) in DM group was higher than that in NC group. The 10-year osteoporotic fracture risk in DM group was lower than that in NC group. Multi-linear regression analysis showed that FRAX score was associated with GHb and the occurrence of hypoglycemia in DM patients. Conclusion Diabetes is an independent risk factor in FRAX. It is a new algorithm model to precisely predict fracture risk in diabetic patients. |
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