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| 肾小管酸中毒伴骨软化继发于干燥综合征1例并文献分析 |
| Renal tubular acidosis associated with acquired hypophosphatemic osteomalacia in elderly women with primary Sjogren ’ s syndrome:A case report and review of the literature |
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| DOI：10.3969/j.issn.1006.7108.2015.12.015 |
| 中文关键词: 干燥综合征 肾小管酸中毒 骨软化症 |
| 英文关键词:Sjogren's syndrome Renal tubular acidosis Osteomalacia |
| 基金项目:常州市武进区科技支撑计划项目（WS201415);上海领军人才队伍建设专项基金（201444) |
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| 中文摘要: |
| 目的 分析干燥综合征（Sjogren’s syndrome,SS)并发肾小管酸中毒伴骨软化症少见首发症状的特点。方法 采用病例回顾方法讨论干燥综合征累及肾小管酸中毒伴骨软化的特点并结合文献复习。结果 Pubmed检索的10例患者均为女性，平均年龄47岁，首发症状均不同，多以（60%)骨痛和肢体无力起病，治疗上纠正酸中毒，中性磷对症治疗，系统性应用糖皮质激素被证明有效。结论 肾小管酸中毒引起的骨软化症起病的患者极易误诊，这种少见表现应作为SS鉴别诊断之一。 |
| 英文摘要: |
| Objective To analyze the characteristics of the hypophosphatemic osteomalacia associated with renal tubular acidosis (RTA) in elderly women with primary Sjogren’s syndrome (SS). Methods Retrospective method was used to report a case of RTA with SS. The associated literatures were reviewed. Results Ten cases of SS and RTA associated with osteomalacia had been reported in women, with a mean age of 47 years old. Bone pain and weakness of the extremities were the first symptom in 60% of the cases. Anti-acidosis treatment, phosphorus treatment, and systemic use of corticosteroids were reported to be effective. Conclusion Patients with osteomalacia due to RTA are easily misdiagnosed. It should be differentially diagnosed with SS. |
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