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| 金天格胶囊在预防绝经后女性骨质疏松性骨折中的作用 |
| The effect of Jintiange capsule on the prevention of postmenopausal osteoporotic fractures |
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| DOI：10.3969/j.issn.1006.7108.2015.12.018 |
| 中文关键词: 骨质疏松 金天格胶囊 骨转化指标 骨密度 |
| 英文关键词:Osteoporosis Jintiange capsule Bone turnover markers Bone mineral density |
| 基金项目:重庆市卫生计生委医学科研项目（20142087) |
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| 中文摘要: |
| 目的 观察金天格胶囊在治疗绝经后女性骨质疏松的疗效，判断其预防骨折发生的概率。方法 选取绝经后骨质疏松女性238名，随机分为4组，第1组：金天格59例，第2组：钙尔奇D +金天格58例，第3组：钙尔奇D +金天格+阿仑膦酸钠 63例，第4组：钙尔奇D +阿仑膦酸钠58例；服药剂量：金天格1. 2mg，tid;钙尔奇D 600mg qd;福善美70mg qw。分别在服药前、服药后3、6个月检测骨密度（bone mineral densities, BMD)、血清1型原胶原N -端前肽（PINP)和1型胶原交联C -末端肽 (CTX)。结果 各组骨密度无明显变化（P >0.05);服药3个月，4组的PINP分别下降了 18.2% ,22. 3% ,62. 3% ,55. 8%，CTX 分别下降了 24. 3% ,29. 7% ,68. 7% ,57. 8% ;服药 6 个月,4 组的 PINP 分别下降了 19. 4% ,23.6% ,63. 5% ,62% ,CTX 分别下降了28. 1%、28.3%、69.9%、64.5%。结论 金天格胶囊可以明显降低骨转化指标，能有效辅助治疗骨质疏松和预防骨折的发生。 |
| 英文摘要: |
| Objective To observe the efficacy of Jintiange capsule on the treatment of osteoporosis and to judge the probability of osteoporotic fracture prevention in postmenopausal women. Methods Two hundred and thirty-eight postmenopausal women with osteoporosis were selected and randomly divided into 4 groups，Group one (Jintiange capsule group，n =59) , Group two (calcium and Jintiange capsule group, n =58)，Group three (calcium and Jintiange capsule and bisphosphonate group, n = 63) , and Group four (calcium and bisphosphonate group, n =58). The dosage of the drugs was 1. 2mg of Jintiange capsule, tid, 600mg of calcium, qd，and 70mg of bisphosphonates，qw. Bone mineral densities ( BMD)，serum procollagen type I amino-terminal propeptide (PINP)，and serum C-terminal cross-linked telopeptides of type I collagen (CTX) were detected before and after 3 months and 6 months of the treatment, respectively. Results BMD was not obviously changed in each group (P >0. 05) . After 3 months of treatment, PINP decreased by 18, 2% , 22. 3% , 62. 3%，and 55. 8%，respectively, in each group, and CTX decreased by 24. 3%，29. 7% , 68.1%，and 57. 8%，respectively, in each group. After 6 months of treatment, PINP decreased by 19. 4% , 23. 6% , 63. 5%，and 62% , respectively, in each group, and CTX decreased by 28. 1% , 28. 3%，69. 9%，and 64. 5% , respectively, in each group. Conclusion Jintiange capsule can obviously decrease bone turnover markers, and can effectively adjuvant the treatment of osteoporosis and prevent osteoporotic fracture. |
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