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| 绝经后2型糖尿病妇女骨质疏松与颈动脉粥样斑块关系的初探 |
| Correlation between atherosclerosis and osteoporosis in postmenopausal women with type 2 diabetes |
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| DOI：10.3969/j.issn.1006.7108.2016.01.015 |
| 中文关键词: 骨质疏松；颈动脉粥样硬化 2型糖尿病；绝经后 |
| 英文关键词:Osteoporosis Carotid arteriosclerosis Type 2 diabetes Post-menopause |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨绝经后2型糖尿病妇女骨质疏松与颈动脉粥样硬化的相关性，为患者的预防治疗提供依据。方法 回顾性分析在我科住院的100例绝经后2型糖尿病妇女，均行颈动脉彩超，观察颈动脉内膜中层的厚度及斑块的情况,依据超声的诊断结果分成有斑块组和无斑块组；采用双能X线骨密度仪检测所有患者腰椎1~4及左髋部的骨密度。结果（1)有斑块组与无斑块组相比，年龄、糖尿病病程、体重指数、血压、血脂、血糖等一般资料在两组间的差异无统计学意义（P均>0.05),而前组第1 ~4腰椎骨密度均值明显低于后组,差异有统计学意义（P均<0.05) ;(2)绝经后2型糖尿病妇女颈动脉内膜中层厚度的均值与腰椎1-4骨密度均值呈负相关（P= -0. 219，P< 0.05)，与空腹血糖、糖化血红蛋白呈正相关（r =0.295 ~0.300,P均<0.05)。结论 在绝经后2型糖尿病妇女中腰椎1-4骨密度的减少是加速颈动脉粥样斑块出现的危险因素，反之粥样斑块形成也促进腰椎骨质的流失，因此治疗和预防时应采用系统性的措施。 |
| 英文摘要: |
| Objective To study the relationship between atherosclerosis and osteoporosis in postmenopausal women with type 2 diabetes, and to provide evidence for the prevention and treatment for the patients. Methods A total of 100 postmenopausal women with type 2 diabetes in our department were included in this retrospective study. Intima-media thickness of carotid artery was examined using color Doppler ultrasound. According to the ultrasonic results all the patients were divided into plaque group and non?plaque group. Bone mineral density of the lumbar vertebrae ( L1-4) and the left hip was detected using dual energy X-ray absorptiometry. Results (1) Compared with those in non-plaque group, age, duration of diabetes, body mass index, blood pressure，lipid，glucose, and other general information had no significant difference (P > 0. 05), The average bone mineral density of L1-4 were lower in plaque group than that in non-plaque group (P <0. 05). (2) The average thickness of carotid intima-media was negatively correlated with bone mineral density of L1-4，and it is positively correlated with fasting blood glucose and glycosylated hemoglobin content (P <0.05). Conclusion The decrease of average of bone mineral density of L1-4 is a risk factor for carotid atherosclerosis in postmenopausal women with type 2 diabetes. Meanwhile, carotid arteriosclerosis may speed up the bone loss of the lumbar vertebra. So it is necessary to take systematic measure to prevent them. |
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