| Objective To study the effect of long-term aerobic exercise on estrogen and the composition of bone in women with osteoporosis. Methods Sixty female patients with osteoporosis from March 2013 to March 2014 in our hospital were enrolled. They were divided into control group (30 cases) and treatment group (30 cases) according to different treatment. Patients in control group conducted aerobic exercise therapy for 3 months, and the patients in treatment group conducted aerobic exercise therapy for 6 months. Changes of the estrogen level and bone composition between the 2 groups were compared. Results The serum estradiol level in the treatment group was 116.3±15.2 pmol/L in 1 month after treatment and 163.0±18.13 pmol/L in 3 months after treatment, respectively. It was 82.7±15.5 pmol/L in 1 month and 107.9±17.1 pmol/L in 6 months, respectively, in the control group. The effect was better in the treatment group than in control group after the treatment, with the statistical significance (P<0.05). Bone mineral density of the hip and the lumbar spine was 0.70±0.17 g/cm2 and 0.95±0.28 g/cm2, respectively, in the treatment group after 6 months, and 0.62±0.12 g/cm2 and 0.84±0.10 g/cm2, respectively, in the control group. The effect was better in the treatment group than in control group after the treatment, with the statistical significance (P<0.05). Conclusion Osteoporosis patients conduct aerobic exercise 3 to 5 times a week, 0.5 1 h each time, and last for 6 months. The effect is significantly better than those conducting aerobic exercise 3 times a week, 0.5 1 h each time, and lasting for 3 months. The long-term exercise can effectively enhance the level of estrogen in women with osteoporosis and improve the patient's bone mineral density. It has obvious preventive effect on osteoporosis. |