| Objective To analyze the change of bone mineral density (BMD) in type 2 diabetic (T2DM) patients with microalbuminuria and ocular fundus retinopathy. Methods The subjects of the study were 49 T2DM patients without microalbuminuria or ocular fundus retinopathy (Group A), 52 T2DM patients with either microalbuminuria or ocular fundus retinopathy (Group B), 43 T2DM patients with both microalbuminuria and ocular fundus retinopathy (Group C), and 60 normal controls (Group N). The BMD of lumbar vertebrae 2-4 (L2-4), left femoral neck, and Ward's triangle region was measured using dual energy X-ray absorptiometry (DEXA). The difference of BMD among the groups was analyzed. Results The BMD of L2-4, left femoral neck, and Ward's triangle region was significantly lower in Group C than that in Group B, A, and normal controls (P<0.05). The BMD of left femoral neck and Ward's triangle region was lower in Group B than in Group A and normal controls (P<0.05). The BMD of left femoral neck and Ward's triangle region was higher in Group A than that in normal controls (P<0.05). BMD was negatively correlated with age, course of disease, fasting blood glucose, hemoglobin a1c, the urinary ratio of albumin to creatinin, but positively correlated with body mass index and fasting insulin in T2DM patients (P<0.05). Conclusion BMD shows an increase trend in T2DM patients without microangiopathy. It significantly reduces when accompanies with microalbuminuria and ocular fundus retinopathy. Fast loss of bone mass occurs in the proximal femur especially. |