| Objective To validate the optimal bisphosphonate in the treatment of osteoporosis using animal models and provide evidence for more appropriate clinical uses of bisphosphonates. Method First we established osteoporotic rabbit models by injecting dexamethasone sodium phosphate intramuscularly. And then the animal models were divided into four different groups and treated with 99Tc-MDP, alendronate and pamironate disodium respectively. The effects of the three different drugs were investigated by comparing with the control group and by analyzing laboratory test, bone histology, bone density, biomechanical test, ROI ratio of 99mTc-MDP bone scintigraphy, X-ray, CT tomography, BALP as well as BGP. The statistical analysis was carried out using SPSS13.0. Result Although all the three methods had relieved the osteoporosis in our experimental groups, 99Tc-MDP is the most effective therapy when compared with alendronate or pamironate disodium. Conclusion Depending on different mechanisms in bone metabolism, the effects of bisphosphonates vary among different therapies. Alendronate is the newly developed bisphosphonate based on pamironate disodium, as a result, it behaves much better when inhibiting bone absorbing in treating osteoporosis. In addition,99Tc-MDP may exerting therapeutic effects through immunization routes. Our research will provide value for more appropriate treatment of osteoporosis. |