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| 经典Wnt信号通路对骨代谢的调节作用 |
| The regulatory role of classic Wnt signaling pathway in bone metabolism |
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| DOI：10.3969/j.issn.1006.7108.2016.03.026 |
| 中文关键词: Wnt通路；因子；成骨细胞 骨质疏松 |
| 英文关键词:Wnt signaling pathway Factor Osteoblast Osteoporosis |
| 基金项目:国家自然科学基金（31501481);黑龙江省自然科学基金（8201115);2013年黑龙江省博士后科研启动金资助（LBH- Q13086) |
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| 中文摘要: |
| Wnt信号通路是一个调控细胞生长、发育和分化的重要信号途径。越来越多的证据表明，经典Wnt信号通路在成骨细胞的分化进程及骨形成过程中扮演着重要角色。本文就经典Wnt信号通路中已知的与骨代谢相关的各个成分及其功能，以及对通过Wnt信号通路防治骨质疏松的研究进展进行了综述，以期能为相关骨代谢性疾病的预防和治疗提供新的思路。 |
| 英文摘要: |
| Wnt signaling pathways are important in regulating the growth, development and differentiation of cells. In recent years, a large number of studies show that the classic Wnt pathway has been shown to play a huge role in the control of osteoblastogenesis and bone formation. In the present review we summarized the current knowledge related to the elements and the known functions of the classic Wnt signaling system in order to further study the classical Wnt pathway of osteoblasts. We also conducted preliminary discussion on the prevention and treatment of osteoporosis through the Wnt signaling pathways, finally developing a new strategy in the prevention and treatment of osteoporosis. |
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