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| 锌指结构Osterix对骨骼发育影响的研究进展 |
| Research of Zinc finger structure Osterix on bone development |
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| DOI：10.3969/j.issn.1006.7108.2016.03.027 |
| 中文关键词: Osterix 骨骼发育；成骨代谢 基因功能 |
| 英文关键词:Osterix Bonedevelopment Osteogenesis metabolism Gene function |
| 基金项目:国家自然科学基金（81273090）,江苏省普通高校研究生科研创新计划项目（KYLX_1264) |
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| 中文摘要: |
| 间充质细胞在骨化形成骨的过程中，其原基会分泌一些Hedgehog，Wnt和FGF家族和TGF-β的转录因子用于调控和起始早期骨骼相关基因的表达，研究这些早期调控因子对于研究期成骨代谢十分重要，锌指结构Osterix基因作为重要的成骨细胞特异性转录因子越来越被人们重视，研究其基因的作用及其相关的机制，利于我们进一步了解成骨代谢和成骨相关性疾病:本文围绕Osterix的发现和功能，Osterix对小鼠中骨骼发育和成骨细胞的影响，Osterix对人类中骨骼的发育影响的研究以 及Osterix的突变与人类骨骼疾病的关系方面进行阐述。目前相关Osterix的综述多集中关注于其对成骨细胞功能的调控。本文主要集中在于对于Osterix在动物和人体骨骼发育的影响的相关报道，进而进一步了解Osterix与人类骨骼疾病的相关的关系。本综述旨在拓展了Osterix作为成骨细胞重要调控因子对于在体的动物和人类骨骼发育的认识。 |
| 英文摘要: |
| Mesenchymal cells in the process of bone ossification formation, its primordium secrete some Hedgehog, Wnt and FGF family and TGF-β transcription factor is used to control and starting early skeletal related gene expression, studying the regulatory factors for the study period of osteogenesis metabolism is very important. The zinc finger structure Osterix gene as a marker of osteoblast been appreciated, studying its genes and their related mechanisms, for us to understand the distribution of metabolic disorders and diseases. The osteogenesis correlation need further to be understood: around the Osterix found and function, Osterix effect on mice skeletal development and for osteoblast differentiation.The Osterix study of human on the effect of the development of bone and Osterix mutation and elaborates the relationship of human bone disease. At present, a lot of related Osterix review focus on the regulation of osteoblast function. This article is mainly about Osterix reports in animal and human body skeleton development, and then further understand Osterix relationship associated with human bone disease. This review aims to expand the Osterix as osteoblasts important regulatory factors in the body of animal and human bonedevelopment. |
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