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| 壮骨方对糖尿病大鼠骨质疏松的防治及其对血清 IGF-l、TNF-α水平的影响 |
| The effect of Zhuanggu-decoction on the treatment and on serum IGF-1 and TNF-α in type 2 diabetes rats with osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2016.04.009 |
| 中文关键词: 中医中药 壮骨方 IGF-l TNF-α 2型糖尿病骨质疏松症 |
| 英文关键词:Traditional Chinese medicine Zhuanggu-decoction IGF-1 TNF-α Type 2 diabetic osteoporosis |
| 基金项目:国家自然科学基金（81160486);广西名老中医民族医传承工作室建设项目（桂卫中[2014]9号文件） |
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| 中文摘要: |
| 目的 探讨壮骨方对糖尿病大鼠骨质疏松进程的干预作用及其对血清IGF-l、TNF-α水平的影响。方法 建立2型糖尿病大鼠模型，分为空白组、模型组、二甲双胍组及壮骨方高、中、低剂量6组，分别给予相应药物灌胃12周。12周后测定各组大鼠全身骨密度，行胫骨干骺端病理切片测定骨计量参数,采用酶联免疫吸附法测定各组血清IGF-1、TNF-α的水平。结果 模型组大鼠的骨密度、骨剂量参数、血清IGF-1水平均明显下降，血清TNF-α表达增高（P <0.01),壮骨方可提高血清IGF-1、 降低TNF-α水平，防止骨密度、骨参数下降（P <0. 01)，且中药高剂量组作用均优于二甲双胍组（P <0. 01)。结论 壮骨方可能通过升高血清IGF-1水平、降低TNF-α水平，进而影响糖尿病骨代谢进程。 |
| 英文摘要: |
| Objective To study the effect of the traditional Chinese medicine，Zhuanggu-decoction，on serum IGF-1 and TNF-α in type 2 diabetes rats during the process of osteoporosis. Methods Rat type 2 diabetic model was established and the rats were divided into 6 groups：blank group, DM group, DM + metformin group (MET), DM + MET + low dose Zhuanggu-decoction (ZGF-L) group, DM + MET + medium dose Zhuanggu-decoction (ZGF-M) group, and DM + MET + high dose Zhuanggu- decoction (ZGF-H) group. The rats were gavaged with corresponding drugs for 12 weeks. After 12 weeks, the bone mineral density, quantitative bone histomorphometry of the tibial stem epiphyseal, and serum IGF-1 and TNF-α were measured in each group. Results The bone mineral density, quantitative bone histomorphometry parameters, and serum IGF-1 decreased, but serum TNF-α increased in DM group (P <0.01). Serum IGF-1 increased, serum TNF-α decreased, and the decrease of bone mineral density and histomorphometry parameters was prevented in Zhuanggu-decoction groups. The effect in DM + MET + ZGF-H group was better than that in DM + MET group (P < 0. 01). Conclusion Zhuanggu-decoction affects osteoporosis process by increasing serum IGF-1 and decreasing serum TNF-α level in type 2 diabetic rats. |
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