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| 抗骨质疏松药物治疗老年股骨转子间骨折疗效分析 |
| Efficacy of anti-osteoporotic drugs on the treatment of osteoporotic intertrochanteric fractures in the elderly |
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| DOI：10.3969/j.issn.1006.7108.2016.04.019 |
| 中文关键词: 骨质疏松性骨折 抗骨质疏松药；老年股骨转子间骨折 维生素D 钙 |
| 英文关键词:Osteoporotic fracture Anti-osteoporotic drug Intertrochanteric fracture in the elderly Vitamin D Calcium |
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| 中文摘要: |
| 目的 观察老年骨质疏松性股骨转子间骨折内固定术后应用有效抗骨质疏松药物治疗的疗效。方法 选取2013年7月至2014年6月在我院60岁以上诊断为骨质疏松的老年股骨转子间骨折患者57例，分为A组（使用抗骨质疏松药物组30 例）和B组（未使用抗骨质疏松药物组27例），骨折术后第5天后行口服维生素D钙咀嚼片、阿伦膦酸钠片治疗，观测骨折愈合时间、骨折并发症、髋关节Harris评分、骨密度。结果 完成随访病例A组26例,B组24例，2组骨折愈合时间、骨折并发症无统计学差异（P>0.05),术后12个月髋关节Harris评分A组高于B组，有统计学意义（P <0. 05) , A组、B组术后3天血清钙及维生素D较术前降低，有统计学意义（P<0.05),A组术后6个月血清钙及维生素D较术前、术后3天增加，有统计学意义（P <0.05),术后6个月A组、B组骨密度较术前无统计学差异（P >0.05)，术后12个月A组骨密度较术前增加，有统计学意义（P <0.05)，术后12个月B组骨密度较术前无统计学差异（P>0.05)。结论 老年骨质疏松性股骨转子间骨折患者术后使用抗骨质疏松治疗能增加骨密度，能获得更好疗效。 |
| 英文摘要: |
| Objective To observe the curative effect of anti-osteoporotic drugs on osteoporotic intertrochanteric fractures after internal fixation in the elderly. Methods Fifty-seven elderly patients, who were over 60 years old and diagnosed with osteoporotic intertrochanteric fractures from July 2013 to June 2014 in our hospital, were selected. They were divided into group A (30 cases, with the use of anti-osteoporotic drugs) and group B (27 cases，without the use of anti-osteoporotic drugs) .Oral D-Cal and alendronate were administered on the fifth day after the surgery. The healing time of the fracture, complications, Harris hip score, and bone mineral density (BMD) were observed. Results Twenty-six cases in group A and 24 cases in group B were completely followed-up. There was no statistical difference in the fracture healing time and complications (P >0. 05) between the two groups. After 12 months of surgery, the score of Harris in group A was higher than that in group B, with statistical significance (P < 0. 05 ). The serum calcium and vitamin D levels was lower in two groups three days after surgery than those before the surgery, with statistical significance (P <0.05). After 6 months of the surgery，the serum calcium and vitamin D levels in group A increased comparing to those before the surgery and three days after surgery, with statistical significance (P < 0. 05 ). BMD in group A and group B was not different in 6 months of the surgery. After 12 months of the surgery, BMD increased in group A, but did not increase in group B, comparing to that before the surgery. Conclusion The use of anti-osteoporotic treatment increases BMD in the elderly patients with osteoporotic intertrochanteric fractures，and obtains better curative effect. |
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