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| 1型糖尿病骨质疏松大鼠模型的建立及评价 |
| Establishment and evaluation of rat type I diabetes and osteoporosis model |
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| DOI：10.3969/j.issn.1006.7108.2016.05.004 |
| 中文关键词: 1型糖尿病模型 糖尿病性骨质疏松 骨形态计量学 |
| 英文关键词:Type 1 diabetic model Diabetic osteoporosis Bone histomorphometry |
| 基金项目:2014年省公益研究与能力建设专项资金 (2014A030304006) |
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| 中文摘要: |
| 目的 建立1型糖尿病性骨质疏松大鼠模型，通过骨形态计量学观察该模型的改变。方法 选取3月龄雄性SD大鼠 60只，随机分为正常对照组（30只）和造模组（30只），造模组腹腔注射STZ 60 mg/kg，诱导建立1型糖尿病性骨质疏松大鼠模型。结果 从血糖、体重、骨密度、骨组织形态计量学证实该方法可以成功制备1型糖尿病性大鼠模型。结论 该方法制备的1型糖尿病性骨质疏松大鼠模型，成模率高，模型稳定。 |
| 英文摘要: |
| Objective To establish type 1 diabetic osteoporosis rat model, and to observe the change of the model using bone histomorphometry. Methods Sixty 3-month-old male Sprague-Dawley (SD) rats were randomly divided into normal control group (30 rats) and diabetic model group (30 rats). Rats in the model group received intraperitoneal STZ injection (60 mg/kg) to establish type 1 diabetic osteoporosis rat model. Results The success of type 1 diabetic osteoporosis rat model was confirmed by determination of blood glucose, body weight, bone mineral density, and bone tissue morphology. Conclusion This method to develop type 1 diabetic osteoporosis rat model is efficient and stable. |
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