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| 细胞因子白细胞介素-6及胰岛素生长样因子-1与类风湿关节炎临床表现的关联性研究 |
| The study of the correlation between IL-6/IGF-1 and the clinical manifestations of rheumatoid arthritis |
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| DOI：10.3969/j.issn.1006.7108.2016.05.010 |
| 中文关键词: 关节炎，类风湿 白细胞介素-6 胰岛素样生长因子-1 |
| 英文关键词:Arthritis Rheumatoid Interleukin-6 Insuiin-like growth factor-1 |
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| 中文摘要: |
| 目的 研究白细胞介素-6 (interleukin-6，IL-6)及胰岛素样生长因子-1 (insulin-like growth factor-1 ,IGF-1)与类风湿关节炎（rheumatoid arthritis，RA)临床表现的关联性。方法 采用酶联吸附免疫法（enzyme linked immunosorbent assay，ELISA )测定 RA患者血清IL-6及IGF-1浓度，分析其于RA临床表现的关联性。结果 1.骨质疏松组IGF-1水平明显低于无骨质疏松组 (P<0.05)。而男性组与女性组、RF阳性组与阴性组、ACCP阳性组与阴性组、无+轻度贫血与中度+重度贫血、白细胞减少与白细胞不减少、血小板升高与无血小板升高之间均无显著性差异（P >0.05)。2. IGF-1与ACCP滴度、RF滴度、病程、ESR、 年龄、CRP均无相关性（P>0. 05),与疼痛关节数及肿胀关节数呈负相关（P<0. 05)。3.男性RA患者IL-6水平明显比女性 RA患者水平低（P<0.05), ACCP阴性组明显比阳性组低（P<0.05)，骨质疏松组明显比无骨质疏松组低（P< 0.05)。而RF 阳性组与阴性组、无+轻度贫血与中度+重度贫血、白细胞减少与白细胞不减少、血小板升高与无血小板升高之间均无显著性差异（P>0.05)。4.IL-6水平与ACCP滴度、疼痛关节数及肿胀关节数呈正相关（P <0.05),与IGF-1水平呈负相关（P< 0.05),与RF滴度、病程、ESR、年龄、CRP
均无相关性（P>0.05)。结论 IL-6及IGF-1与RA病情活动有关。女性患者IL-6高，易于发生骨质疏松。 |
| 英文摘要: |
| Objective To investigate the relationship between interleukin-6 (IL-6)/insulin-like growth factor-1 (IGF-1) and the clinical manifestations of rheumatoid arthritis (RA). Methods The enzyme-linked immunosorbent assay was used to determine the serum levels of the IL-6 and IGF-1. Results 1) The level of IGF-1 was lower in RA patients with osteoporosis than in those without osteoporosis (P< 0, 05). The level of IGF-1 was not different between males and females, positive and negative of RF group, positive and negative of ACCP group, patients with non or mild anemia and with moderate or severe anemia, patients with hypoleucocytosis and without hypoleucocytosis，patients with thrombocytosis and without thrombocytosis (P> 0, 05). 2) The level of IGF-1 was not correlated with the levels of ACCP and RF titers, disease course, ESR, age, and CRP (P > 0.05), but was negatively correlated with the number of the pain joint and the swollen joint (P < 0.05). 3) The level of IL-6 was lower in males than in females，was lower in ACCP negative group than in ACCP positive group，and was lower in osteoporosis group than in non?osteoporosis group (P <0. 05). It was not significantly different between patients with RF factor positive and negative, with non or mild anemia and with moderate or severe anemia,with hypoleucocytosis and without hypoleucocytosis, with thrombocytosis and without thrombocytosis (P> 0. 05) .4) The level of IL-6 was positively correlated with the number of the pain joint and the swollen joint (P < 0. 05) , negatively correlated with the level of IGF-1 (P < 0. 05) , and not correlated with RF titers，disease course, ESR，age，and CRP (P > 0.05). Conclusion The action of RA is related to the levels of IL-6 and IGF-1. Females have higher level of IL-6 and are easy to develop osteoporosis. |
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