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| 鲑鱼降钙素联合依帕司他对老年2型糖尿病伴骨质疏松患者周围神经病变疼痛的疗效观察 |
| Efficacy of salmon calcitonin combined with epalrestat on peripheral neuropathy pain in type 2 diabetic elderly patients with osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2016.05.016 |
| 中文关键词: 2型糖尿病 骨质疏松症 糖尿病周围神经痛 鲑鱼降钙素 依帕司他 |
| 英文关键词:Type 2 diabetes mellitus Osteoporosis Diabetic peripheral neuropathic pain Calcitonin Epalrestat |
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| 中文摘要: |
| 目的 观察鲑鱼降钙素联合依帕司他对老年2型糖尿病（T2DM)伴骨质疏松患者周围神经病变（DPN)疼痛的疗效。 方法 选择老年2型糖尿病周围神经病变伴骨质疏松的患者78例，采用密歇根神经病变筛査量表（MNSI)与密歇根糖尿病神经病变评分量表（MDNS)评分后，随机分为实验组（A组,40例）和对照组（B组，38例）。A组予以骨质疏松症基础治疗药物（钙剂、维生素D)的基础上,再给予鲑鱼降钙素联合依帕司他,B组予以骨质疏松症基础治疗基础上，给予甲钴胺联合依帕司他，分别于实验开始时以及实验后4周进行MNSI、MDNS以及疼痛评分。疼痛评分联合采用主客观评价法，即主诉疼痛程度分级法（VRS法）、视觉模拟法（VAS划线法）、Wong-Banker面部表情量表法（FPS-R)。结果 两组间疗效差异有统计学意义,患者主观感觉在实验开始时其差异无统计学意义,但实验4周后差异有统计学意义。结论 鲑鱼降钙素联合依帕司他对 T2DM伴骨质疏松患者的DPN疼痛具有改善作用,且呈时间依赖性，4周以上疗效显著。 |
| 英文摘要: |
| Objective To observe the efficacy of salmon calcitonin combined with epalrestat on peripheral neuropathy (DPN) pain in elderly patients with type 2 diabetes mellitus (T2DM) and osteoporosis. Methods Seventy-eight elderly T2DM cases with DPN and osteoporosis were selected. After application of the Michigan neuropathy screening scale (MNSI) and Michigan diabetic neuropathy rating scale (MDNS) , they were randomly divided into experimental group (A, 40 patients) and control group (B, 38 patients). Patients in group A received salmon calcitonin combined with epalrestat, while patients in group B received basic treatment of osteoporosis drugs (calcium and vitamin D) combined with epalrestat. MNSI, MDNS, and pain score were evaluated in 4 weeks. Pain scores and subjective pain evaluation methods, VRS, VAS, and FPS-R, were used. Results Statistical analysis of the results suggested that the difference of the efficacy between the two groups was statistically significant. The subjective feeling of the patients was not significantly different at the beginning, but it was statistically significant after 4 weeks. Conclusion Salmon calcitonin combined with epalrestat can relieve DPN pain in elderly patients with T2DM and osteoporosis. The effect is time- dependent, and it is remarkable after 4 weeks. |
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