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| 金天格胶囊配合依降钙素治疗膝骨性关节炎合并骨质疏松症的临床疗效观察 |
| The Clinical efficacy of the application of Jintiange capsule combined with calcitonin on knee osteoarthritis with osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2016.05.020 |
| 中文关键词: 金天格胶囊 依降钙素注射液 膝骨性关节炎；骨质疏松症 |
| 英文关键词:Jintiange capsule Calcitonin Osteoarthritis Osteoporosis |
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| 中文摘要: |
| 目的 观察金天格胶囊配合依降钙素治疗膝骨性关节炎合并骨质疏松症的临床疗效。方法 将我院宋氏正骨科门诊就诊的90例患者，均经过临床X线和骨密度检查确诊,随机分为两组，治疗组（45例）给予口服金天格胶囊配合依降钙素皮内注射,对照组(45例）予以口服醋氯芬酸片配合依降钙素注射液皮内注射,治疗4周停药后继续观察6个月，通过对服药前及服药后4周及停药后6个月进行记录骨关节炎指数（WOMAC)评分,生化指标检测，采用Lequesne膝关节功能评分评定患者生活能力，并经过1年的门诊随访,总结其疗效。结果 对照组的疼痛缓解时间和功能恢复情况与治疗组相比差异有统计学意义（P< 0. 01)。结论 金天格胶囊配合依降钙素治疗膝骨性关节炎合并骨质疏松症患者不仅能够早期阻断病情发展、改善关节功能，又能长期维持疗效，提高活动度和改善生活质量,而且在临床治疗中安全、有效，能够顺应临床治疗并起到积极作用。 |
| 英文摘要: |
| Objective To evaluate the efficacy of Jintiange capsule combined with calcitonin on the treatment of knee osteoarthritis with osteoporosis. Methods Ninety patients in the Song outpatient department of our hospital were diagnosed using X-Ray examination and BMD. They were randomly divided into two groups. Patients in the experimental group (45 cases) received Jintiange capsule combined with the subcutaneous injection of calcitonin. Patients in the control group (45 cases) received oral aceclofenac combined with calcitonin the subcutaneous injection of calcitonin. The treatment lasted for 4 weeks and the follow up lasted for 6month. WOMAC osteoarthritis index, biochemical indexes, and Lysholm knee function score were evaluated before the treatment and 4-week and 6-month after discontinuation of the medicine. After 1 year of outpatient follow-up, the efficacy was summarized. Results The difference of pain relief time and function recovery between the treatment group and the control group was statistically significant (P <0, 01). Conclusion Jintiange capsule combined with calcitonin treatment of knee osteoarthritis with osteoporosis can not only block the disease development and improve joint function, but also can maintain its long-term curative effect, improve the activity and the quality of life. The treatment is safe, effective, and able to adapt in the clinic. |
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