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| TNF-α与干细胞成骨分化 |
| TNF-alpha and osteogenic differentiation by stem cells |
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| DOI：10.3969/j.issn.1006.7108.2016.05.022 |
| 中文关键词: TNF-α 成骨分化 干细胞 信号通路 |
| 英文关键词:TNF- alpha Osteogenic differentiation Stem cells Signaling pathway |
| 基金项目:教育部“创新团队发展计划”（IRT1270);国家自然科学基金青年基金（81403239);上海中医药大学“085工程”中医药 学一流学科建设项目“引导创新计划”（085ZY1204);国家自然科学基金重大国际合作项目（81220108027) |
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| 中文摘要: |
| 肿瘤坏死因子α(tumor necrosis factor α, TNF-α)在干细胞向成骨分化过程中扮演着双重角色（促进或抑制成骨分化），其过程受到多条信号通路调控,如Wnt、BMP-Smads、MAPK、NF-κB等信号通路。而TNF-α的作用时间、作用浓度及作用的干细胞类型又可能是决定其促进或抑制干细胞成骨分化的主要因素。本文就以TNF-α对干细胞成骨分化作用的相关信号通路及可能决定因素做一简要概述。 |
| 英文摘要: |
| Tumor necrosis factor α (TNF-α) plays dual function role in osteogenic differentiation by stem cells (promoting or inhibiting osteogenic differentiation). The process is regulated by multiple signaling pathways, including Wnt, BMP-Smads, MAPK, and NF-kappa B signaling pathways. The treatment time and dosage of TNF-α and the type of the stem cell might be important factors to determine the effect of TNF-alpha on stem cell osteogenic differentiation. In this review, signaling pathways and potential factors involved in stem cell osteogenic differentiation with TNF-α treatment are discussed. |
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