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| 骨关节炎软骨下骨的微结构改变 |
| Microstructural changes of the subchondral bone in osteoarthritis |
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| DOI：10.3969/j.issn.1006.7108.2016.05.023 |
| 中文关键词: 骨关节炎；软骨下骨 微损伤 骨髓水肿样病变；骨囊肿 |
| 英文关键词:Osteoarthritis Subchondral bone Microdamage Bone marrow edema-like lesions Subchondral bone cysts |
| 基金项目:福建省卫生厅青年科研课题项目资助（2013-2- 117);卫生部国家临床重点专科建设项目资助（2012-122);国家中医药管理局“十二五”重点专科建设项目资助（2012-2) |
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| 中文摘要: |
| 骨关节炎（OA)是老年人中常见疾病，在过去几十年中，软骨下骨组织结构的改变被认为在OA病因中起重要参与作 用，软骨下骨微结构损伤将导致其加重。OA病理进程中可以在软骨下骨检测到一些微结构改变，包括微损伤，骨髓水肿样病变和骨囊肿等。关节软骨下骨的微结构改变与骨关节炎进展高度相关，软骨下骨微结构损伤将导致骨关节炎的加重,保持软骨下骨的完整性可作为防治骨关节炎的方法之一。了解OA软骨下骨的微结构改变，阐明骨关节炎软骨下骨微结构损伤的发生机理及其与骨关节炎发生发展间关系，将有助于OA的诊断、预防和治疗。 |
| 英文摘要: |
| Osteoarthritis (OA) is a common disease in elderly people. In the past decades，subchondral bone structure is believed to play an important role in the pathogenesis of OA. Subchondral bone microstructure damage may aggravate OA. During the progress of OA, subchondral bone microstructural changes are detected, including microdamage, bone marrow edema-like lesions, subchondral bone cysts, and so on. The change of subchondral bone microstructural is highly related with the development of OA. The damage of subchondral bone microstructural results in the severity of OA. Preservation of the integrity of subchondral bone is one of the prevention methods in OA. Understanding subchondral bone microstructural changes and the role of subchondral bone in osteoarthritis may help us to diagnosis, prevent, and treat OA. |
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