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| 植物雌激素防治骨质疏松作用的机制进展 |
| Research progress in the mechanism of phytoestrogens in the prevention and treatment of osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2016.05.025 |
| 中文关键词: 植物雌激素；结构类型 骨质疏松 机制研究 |
| 英文关键词:Phytoestrogens Chemical structures Osteoporosis Mechanism study |
| 基金项目:江苏省骨科临床研究中心（BL2012002 )，南京市科研课题（201402007)，中国博士后基金（2014M552632) |
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| 中文摘要: |
| 植物雌激素是一类从植物中分离得到且能与机体雌激素受体结合，产生雌激素样作用的非甾体类化合物。植物雌激素存在于许多食用或药食同源的植物中，主要分布于豆科植物中，根据其化学结构可分为：异黄酮类、木脂素类、香豆素类等。 植物雌激素具有促进骨形成，抑制骨吸收的作用，并对骨髓间充质干细胞（BMSCs)骨代谢有重要作用，在骨质疏松的防治中引起广泛关注。本文从植物雌激素的植物来源、结构类型及在防治骨质疏松中的作用机制等最新研究进展展开综述，为其临床应用和深入研究提供新思路。 |
| 英文摘要: |
| Phytoestrogens are the class of non-steroidal compounds isolated from plants. They bind to estrogen receptors and function similar to estrogen. Phytoestrogens are known to be abundant in edible and/or medicinal plants，mostly belonging to the Leguminosae family. According to their chemical structures, phytoestrogens can be divided into isoflavonoids，lignans, coumarins, and miscellaneous classes. Phytoestrogens attract broad attention for their ability of promoting bone formation, inhibiting bone absorption, and playing important role in bone mesenchymal stem cells (BMSCs) and bone metabolism. This paper reviews the plant resources, chemical constituents, and recent progress of phytoestrogens in the treatment of osteoporosis, and provides new idea in the clinical studies. |
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