| Objective To discuss the relationship between bone mineral density (BMD) and sex hormone in male patients with type 2 diabetes mellitus (T2DM) by detecting the sex hormone at the varied BMD status. Methods The data of 84 45-60-year-old male patients with T2DM in our hospital from June 2013 to January 2015 were collected. BMD of the lumbar vertebrae (L1-L4), femoral neck (FN), and total hip (TH) in all patients was measured using dual energy X-ray absorptiometry. The subjects were divided into normal bone mass group and abnormal bone mass group (including bone mass loss and osteoporosis), according to BMD results. The height, weight, systolic blood pressure (SBP), and diastolic blood pressure (DBP) were measured and recorded, The fasting blood glucose (FBG), postprandial blood glucose (PBG), glycated hemoglobin (HbA1c), cholesterol(TC), triglyceride (TG), low density lipoprotein (LDL), testosterone (T), estradiol (E2), luteinizing hormone (LH), and follicle stimulating hormone (FSH) were detected. Body mass index (BMI) was calculated. Results 1. Comparing with the normal bone mass group, the abnormal bone mass group had a longer disease duration (8.3±6.9 vs 6.8±6.5, P<0.05), lower BMI (22.7±2.3 vs 23.9±2.6, P<0.05), and significantly lower levels of E2 and T (79.5±19.0 vs 101.1±28.5, 10.9±2.4 vs 15.4±6.7, respectively, P<0.05). 2. Pearson correlation analysis revealed that the levels of T was positively correlated with the BMD of L1-L4, FN, and TH (r=0.32, r=0.26, r=0.26, respectively, P<0.05); E2 was positively correlated with BMD in TH (r=0.026, P<0.05); TC and LDL were negatively correlated with BMD in FN (r=-0.29, r=-0.28, respectively, P<0.05). 3. Multivariate linear regression analysis showed that T and TC were the main affecting factors of BMD in male patients with T2DM, while E2, FSH, and LH did not enter the regression model. Conclusion E2, T, TC, and LDL are correlated with BMD in male patients with T2DM. T of the sex hormone is the independent risk factor for BMD in male patients with T2DM. |