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| 鲑鱼降钙素联合海滨疗养因子对老年性骨质疏松症骨密度和骨转换指标影响的研究 |
| The effect of salmon calcitonin combined with seaside comprehensive rehabilitation factors on bone mineral density and bone turnover markers in aged osteoporosis patients |
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| DOI：10.3969/j.issn.1006-7108.2016.06.018 |
| 中文关键词: 鲑鱼降钙素 海滨疗养因子 骨质疏松症 骨密度 骨转换指标 |
| 英文关键词:Salmon calcitonin Seaside comprehensive rehabilitation factors Osteoporosis Bone mineral density Bone turnover markers |
| 基金项目:2009-2010年山东省医药卫生科技发展计划（保健项目9号） |
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| 中文摘要: |
| 目的 观察鲑鱼降钙素联合青岛海滨疗养因子综合治疗方案对骨代谢的影响。方法 研究组：口服钙尔奇D600mg每日1次或其他钙片的同时，采用鲑鱼降钙素50IU肌肉注射，每日1次，连用2w后改为隔日1次，连续使用6个月，同时联合海滨疗养因子，每周3~5次，每次1h以上；对照组：单纯采用口服钙尔奇D600mg每日1次或其他钙片，连续使用6个月。观察两组及组间用药前后骨密度(BMD)、骨转换指标变化、骨痛和生活能力评价。结果 ①骨密度变化：研究组治疗6个月后，腰椎L2-4、股骨颈部的骨密度较治疗前明显升高(P<0.05)，Ward区骨密度无显著性改变，而对照组各部位骨密度较用药前无明显改变(P>0.05)。②血生化中血钙、血磷及碱性磷酸酶指标值：两组生化指标在治疗前后无显著差异(P>0.05)。③治疗6个月后血清降钙素的水平明显升高，骨钙素水平明显降低。④疼痛程度改善情况：两组治疗前后疼痛分级比较，研究组疼痛明显改善。⑤生活质量改善情况(以生活能力提高为指标)：研究组生活质量改善有效率为88.5%，而对照组仅为36.2%，两组有效率相比有显著差异(P<0.01)。结论 鲑鱼降钙素联合海滨疗养因子应用于老年性骨质疏松症患者，不仅能够增加骨密度而且可以减少骨质疏松症引起的疼痛，临床效果确切，患者依从性好，值得临床推广。 |
| 英文摘要: |
| Objective To observe the effect of salmon calcitonin combined with Qingdao seaside rehabilitation factors on bone mineral density and bone turnover markers. Methods The patients in the research group received 600 mg of calcium and 50 IU of salmon calcitonin injection for 6 months combined with beach rehabilitation factor, 3-5 times a week, over 1h per time. The patients in the control group received 600mg of calcium per day only for 6 months. Bone mineral density (BMD), changes of bone turnover markers, bone pain, and life ability were observed before and after the treatment. Results 1) After 6 months, BMD of L2-4 and the femoral neck significantly increased in the research group (P<0.05). No significant change in BMD of the Ward’s region was observed. BMD in the control group was not significantly changed after the treatment (P>0.05). 2) Serum levels of calcium, phosphorus, and alkaline phosphatase were not significantly different between the two groups before and after the treatment (P>0.05). 3) Serum levels of calcitonin significantly increased, but osteocalcin level significantly decreased after 6 months. 4) After the treatment, the degree of pain in the research group relieved significantly comparing to that in control group. 5) The improvement of the quality of life in the research group was 88.5%, while it was only 36.2% in the control group. The difference between the two groups was significant (P<0.01). Conclusion Salmon calcitonin combined with Qingdao seaside rehabilitation factors is effective in treating senior osteoporosis. It can increase BMD and reduce the pain caused by osteoporosis. It is worthy of clinical promotion. |
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