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| 广州地区骨质疏松症患者冬季维生素D水平现状分析 |
| Vitamin D status of Guangzhou osteoporosis patients in winter |
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| DOI：10.3969/j.issn.1006-7108.2016.06.019 |
| 中文关键词: 骨质疏松症 25-羟维生素D 维生素D |
| 英文关键词:Osteoporosis 25-hydroxyvitamin D Vitamin D |
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| 中文摘要: |
| 目的 调查广州地区冬季骨质疏松症患者体内维生素D(VitD)水平的状况。方法 随机选取 2014年12月至2015年2月我院299例年龄≥50岁骨质疏松症患者，采集其清晨空腹静脉血，所有研究对象均采用Cobase 6000型电化学发光仪(瑞士, 罗氏诊断)检测血清25-羟维生素D(25(OH)D)和甲状旁腺激素(PTH)水平，日立 7180型自动生化分析仪测定钙(Ca)、磷(P)及碱性磷酸酶(ALP)水平。双能X 线吸收仪检测腰椎和股骨近端骨密度(BMD)，SPSS 16.0软件进行数据分析。结果 299 例骨质疏松症患者，其中男性患者63例，25(OH)D平均水平为(52.75±17.30)nmol/L，女性患者236例，25(OH)D平均水平(53.97±16.11)nmol/L。其中VitD 正常者仅占3.3%，缺乏者占47.6%，不足者占44.8%，严重不足者占4.3%。这些患者普遍存在着25(OH)D水平不足现象，其中VitD缺乏和不足所占比例较大，且男女两组的25(OH)D水平无统计学差异。结论 本研究显示广州地区冬季骨质疏松症患者25(OH)D不足和缺乏现象较普遍，且无性别差异，补充足量VitD，需要重视及积极治疗，定期监测25( OH) D水平，为临床骨质疏松症的防治提供一定的数据参考。 |
| 英文摘要: |
| Objective To investigate the serum 25-hydroxyvitamin D (25(OH)D) level of Guangzhou osteoporosis patients in winter. Methods A total of 299 osteoporosis patients aged over 50 years were randomly selected from December 2014 to February 2015 in Guangzhou. Serum 25(OH)D and PTH were determined using electrochemiluminescence (Rocher, Swiss). Serum Ca, P, and ALP were determined using Hitachi 7180 automatic biochemical analyzer (Japan). Bone mineral density (BMD) of the lumbar spine and the proximal femur were measured using dual-energy X-ray absorptiometry (GE lunar prodigy). The data were analyzed using a SPSS 16.0 software. Results Of the 299 osteoporosis patients, 63 were males with an average level of 25(OH)D of 52.75±17.30 nmol/L, and 236 were females with an average level of 25(OH)D of 53.97±16.11 nmol/L. The normal VitD status accounted for only 3.3%, VitD deficiency for 47.6%, insufficiency of vitamin D for 44.8%, and serious VitD deficiency for 4.3%. VitD insufficiency existed generally in osteoporosis patients. There was no statistic difference between males and females. Conclusion VitD deficiency in winter is popular in Guangzhou osteoporosis patients without gender difference. These patients need to pay more attention and actively treatment. 25(OH)D level should be regularly monitored. This study provides certain reference for the prevention and treatment of osteoporosis. |
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