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| 成都地区不同年龄城乡妇女维生素D和骨代谢指标及骨密度的状况分析 |
| Investigation and analysis of vitamin D, bone metabolic markers, and bone mineral density in females of different age in Chengdu |
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| DOI：10.3969/j.issn.1006-7108.2016.06.021 |
| 中文关键词: 25-羟基维生素D 骨代谢指标 骨密度 |
| 英文关键词:25-hydroxyvitamin D Bone metabolic markers Bone mineral density |
| 基金项目:成都市科技厅（2015-HM01-00281-SF）；四川省卫生厅科研项目（150024）；成都市内分泌学会青年基金项目（2012005） |
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| 中文摘要: |
| 目的 评价成都市不同年龄城乡女性居民血清25-羟基维生素D水平并计算维生素D缺乏和不足的患病率，计算各种骨转换指标的平均值，研究维生素D水平与骨转换指标的关系。方法 选择2个城镇社区和2个农村社区，30~90岁健康妇女376例，采用酶联免疫法测定1,25-二羟基维生素D、25-羟基维生素D，化学发光免疫分析法测定骨碱性磷酸酶、胶原C端肽、N端骨钙素、抗酒石酸酸性磷酸酶、甲状旁腺素、1型前胶原氨基，用双能X线吸收仪检测腰椎骨密度。结果 25-羟基维生素D平均值为17.2±0.7ng/mL，N端骨钙素平均值为7.6±0.3ng/mL，1型前胶原氨基端肽平均值为59.6±4.2ng/mL，维生素D不足者患病率为：97.0%，缺乏者患病率为：76.86%。同时，25-羟基维生素D与胶原C端肽、抗酒石酸酸性磷酸酶呈负相关，1,25-二羟基维生素D与骨碱性磷酸酶呈正相关关系。50岁以后骨密度显著下降。结论 成都市女性居民在冬季维生素D普遍不足，不良的生活方式及低维生素D的摄人应引起重视。 |
| 英文摘要: |
| Objective To evaluate the level of serum 25-hydroxyvitamin D and bone metabolic markers in female residents of different age and region in Chengdu, to calculate the prevalence of vitamin D deficiency, and to study the relationship between vitamin D and bone metabolic markers. Methods A total 376 cases of 30-90 years old healthy women were selected from two urban region and two rural communities. The levels of 1,25-hydroxyvitamin D and 25-hydroxyvitamin D were detected using enzyme linked immunosorbent assay. The levels of bone alkaline phosphatase, collagen C peptide, N end of osteocalcin, resistant acid phosphatase, parathyroid hormone, and type I procollagen amino terminal peptide were determined using chemiluminescence immunoassay method. Bone mineral density of the lumbar vertebrae was measure using DXA. Results The mean values of 25-hydroxyvitamin D, N-terminal osteocalcin, and type I procollagen amino terminal peptide were 17.2±0.7 ng/ml, 7.6±0.3 ng/ml, and 59.6±4.2 ng/ml, respectively. The prevalence of vitamin D deficiency and insufficient was 97% and 76.86%, respectively. There was a negative correlation between 25-hydroxyvitamin D and collagen C peptide and resistant acid phosphatase. 1,25-hydroxyvitamin D and bone alkaline phosphatase were positively correlated. Conclusion This study shows that vitamin D is generally inadequate in women of Chengdu in winter. Unhealthy lifestyle and low vitamin D intake should be taken into account. |
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