| China is country that has the most elderly population in the world, accounting for one-fifth of the total elderly population of the world. As the elderly population, especially the elderly obesity population, continuously increases, the number of people with bone and joint degenerative diseases increases greatly. Bone and joint degenerative disease is one of the focuses in the medical field, but its clinical treatment is still a difficult problem. This problem is especially important in China, which the population is going into aging. At present, no appropriate animal model is suitable for the study of degenerative diseases, which is one of the causes for the difficulty of drug screening in the treatment of bone and joint degenerative diseases. Thioacetamide (TAA) induces liver fibrosis with stable and reproducible characteristics, so the drug is used in the preparation of liver fibrosis animal model commonly. Our laboratory found in animal experiments TAA leads to bone and joint disease in experimental animals. Many reports in the literatures show that TAA leads to bone destruction while it induces liver fibrosis. Therefore, we speculate that a bone and joint degeneration animal model can be established by using TAA. The establishment of TAA-induced bone and joint degeneration animal model can not only confirm the relationship between TAA and bone and joint diseases, but also provide a research platform for the study of pathogenesis and clinical treatment of bone and joint degenerative disease. The existence of TAA in nature, its transformation form, pathways into the body, accumulation parts in the body, the damage to the human organs, and social environmental issues can also been investigated. |