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| 骨质疏松症与表观遗传学 |
| Osteoporosis and epigenetics |
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| DOI：10.3969/j.issn.1006.7108.2016.07.026 |
| 中文关键词: 骨质疏松症 表观遗传 DNA甲基化 组蛋白修饰 miRNA |
| 英文关键词:Osteoporosis Epigenetics DNA methylation Histone modification miRNA |
| 基金项目:国家自然科学项目（81001532);广东省科技计划项项目（2010B030700076 )；广东省科技计划项项目 (2013B021800162);广州市珠江科技新星项目（2012J2200037 );佛 山市科技计划项目（2012AA100662) |
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| 中文摘要: |
| 骨质疏松症是老年人常见的退行性疾病，老龄化的社会结构也使得骨质疏松症具有广泛的发病人群，其继发骨折的风险较高，危害性大。骨质疏松症以骨强度下降,骨折风险增加为特征的一种全身性骨骼系统疾病，它受年龄、性别、体内性激素水平、遗传、环境等多方面因素的影响。近年来，随着基因技术的发展，遗传因素与骨质疏松症的相关研究也逐渐增加，其热点之一为表观遗传学。表观遗传是不同于传统孟德尔遗传定律，不通过改变DNA序列所致的可遗传的基因表达变化，它包括DNA甲基化、组蛋白修饰、微小RNA(miRNA)、染色质重塑等。本文就骨质疏松症与表观遗传学的研究现状进行阐述，旨在揭示骨质疏松症在表观遗传学方面可能的发病机制。 |
| 英文摘要: |
| Osteoporosis is a common degenerative disease in the elderly. The aging of the social structure makes the onset of osteoporosis more extensive in the population. It has a high risk of fractures and a hazardous consequence. Osteoporosis is a systemic skeletal system disease characterized by decreased bone strength and increased risk of fracture. It is influenced by age, sex, sex hormone levels in the body, genetics, environment, and other factors. In recent years, with the development of genetic technology, the correlation research between genetic factors and osteoporosis also gradually increases. One of the hot spots is epigenetics. Epigenetics includes DNA methylation, histone modification, miRNA, chromatin remodeling, which is different from the traditional Mendel ’ s law by changing the DNA sequence. This paper elaborates the research status of osteoporosis and epigenetics, aiming at revealing the pathogenesis of osteoporosis in epigenetics. |
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