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| 晚期氧化蛋白产物与骨质疏松症的研究进展 |
| The research progress of the relationship between advanced oxidation protein products and osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2016.07.029 |
| 中文关键词: 晚期氧化蛋白产物 氧化应激 骨质疏松症 成骨细胞 破骨细胞 |
| 英文关键词:Advanced oxidation protein products Oxidative stress Osteoporosis Osteoblasts Osteoclasts |
| 基金项目:南方医科大学南方医院院长基金（2014C020) |
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| 中文摘要: |
| 骨质疏松症（osteoporosis, OP)是一种受遗传和环境因素共同影响的代谢性疾病，其主要特点是骨量低下、骨脆性增加、易发生骨折。其发病病因多样,分子机制复杂，已成为影响人们特别是老年人生活质量的流行病之一。晚期氧化蛋白产物是一种新的氧化应激标志物，通过增加细胞活性氧释放、促使炎症因子生成，在促进衰老及老年相关性疾病发生发展中起到重要作用。本文就晚期氧化蛋白产物对骨形成主要细胞和破骨细胞的影响和作用机制，以及治疗骨质疏松症的新型抗氧化药 物的研究进展做一综述。 |
| 英文摘要: |
| Osteoporosis (OP) is a kind of metabolic disease characterized by bone mass loss, fragility of the bone and increase of bone fracture risk, which is associated with genetic and environmental factors. Osteoporosis has become one of the common diseases affecting the living quality of the elderly for its diverse pathogenesis and complicated molecular mechanism. Advanced oxidation protein products, a kind of novel marker of oxidative stress, play an important role in aging process and age-related diseases by increasing the release of reactive oxygen and promoting the generation of inflammatory cytokines. In this paper, we are going to review the effects and mechanisms of advanced oxidation protein products on the primary cells during bone formation and osteoclasts and the research progress of new antioxidants for osteoporosis. |
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