| Objective To study the effect of lycopene and exercise on bone metabolism in ovariectomized rats，and to explore the relevant mechanism. Methods 6 month old female Wistar rats, were random divided into 6 groups stratified by body mass： sham group (sham), OVX group (OVX group), OVX + E group (OVX + Exercise group), OVX + L group (OVX + lycopene group)， OVX + E + L group (OVX + Exercise + lycopene group), OVX + A group (ovariectomy + alendronate group). After 12 weeks, the relevant indicators were tested. Results (1) Treadmill exercise could decrease fat body mass and improve OC (bone formation marker) levels in ovariectomized rats, as well as improve trabecular number and inhibit bone resorption. (2) Lycopene mono?therapy could improve uterine weight and serum thyroid hormone level, and decrease the level of NTX in ovariectomized rats. It also increased the relative bone volume, trabecular thickness and bone formation rate, and promoted bone formation. (3) Exercise in combination with drug treatment could decrease the percentage of body fat in ovariectomized rats, increase the level of serum estradiol, and reduce the level of 8-OHdG and DPD in urine. It also improved the structural parameters of trabecular bone, the rate of bone formation, bone strength and resistance, and whole body bone mineral density in ovariectomized rats. Conclusion (1) Moderate treadmill exercise can prevent bone loss and improve bone health in ovariectomized rats. (2) The effects of lycopene on bone metabolism in ovariectomized rats was similar to that of alendronate after 12 weeks, including increased bone strength, reduced oxidation, enhanced function of the antioxidant system and maintenance of bone metabolism balance. (3) Lycopene and exercise showed great synergistic effect, and had positive effects on bone remodeling in ovariectomized rats. |