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| 阿托伐他汀联合阿仑膦酸钠治疗老年性骨质疏松的临床疗效及安全性 |
| To evaluate the efficacy and safety of atorvastatin combined with alendronate in the treatment of senile osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2016.08.020 |
| 中文关键词: 阿托伐他汀 阿仑膦酸钠 骨质疏松症 临床疗效 |
| 英文关键词:Atorvastatin Alendronate Osteoporosis Clinical effect |
| 基金项目:河南省医学科技攻关计划项目（201303123) |
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| 中文摘要: |
| 目的 对阿托伐他汀联合阿仑膦酸钠治疗老年性骨质疏松的临床疗效及安全性进行分析。方法 选取2012年9月- 2016年3月于我院治疗的178例老年性骨质疏松患者进行研究，按照患者血脂情况进行分组,A、B两组分别89例，给予B组患者（血脂正常）服用阿仑磷酸钠药物进行治疗，在此基础上给予A组患者（血脂轻度异常）联合服用阿托伐他汀药物进行治疗，在治疗24周后，将两组患者的疼痛VAS评分、血钙、碱性磷酸酶、血磷、骨密度、I型胶原竣基末端肽（CTX)、骨钙素、I型 胶原氨基末端肽（NTX)、甲状旁腺素（PTH)、25-羟基维生素D(25-(OH)D)变化情况进行对比，同时对患者服药后的不良反应发生率进行比较。结果 A组患者的NTX、CTX含量、VAS评分、腰椎、股骨处骨密度、股骨颈明显高于B组患者，其他指标差距不大，无统计学意义（P >0.05)，两组患者的不良反应发生率相比，无统计学意义（P> 0.05)。结论 评价阿托伐他汀联合阿仑膦酸钠治疗老年性骨质疏松具有显著疗效，安全性较高，值得在临床中推广应用。 |
| 英文摘要: |
| Objective To examine the clinical efficacy and safety of Atorvastatin combined with Alendronate in the treatment of senile osteoporosis. Methods The study was conducted in 178 cases of senile osteoporosis who were selected from patients attending clinics of our hospital from September 2012 to March 2016. Patients were grouped according to serum lipids, with 89 patients in each group (A, B). Patients in group B (with normal blood lipids) were given alendronate，and patients in group A (mild abnormal blood lipids) received combined Atorvastatin and Alendronate treatment. After 24 weeks of treatment, comparisons were made between the two groups on the changes in pain VAS score, serum calcium, serum phosphorus, alkaline phosphatase, bone mineral density，tartrate resistant acid phosphatase -5 b, bone alkaline phosphatase，type I collagen carboxy terminal peptide， osteocalcin and collagen amino terminal peptide, and the incidence of adverse reactions. Results Patients in group A had significantly higher NTX and CTX levels, VAS score, lumbar spine and femoral neck BMD than those of group B, other indicators did not differ significantly (P > 0. 05). The incidence of adverse reactions in the two groups was not significantly different (P > 0. 05). Conclusion The combination of atorvastatin with atorvastatin in the treatment of senile osteoporosis is effective and safe, and suitable for wider clinical application. |
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