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| 有限元分析在骨质疏松症临床研究的应用进展 |
| Progress on the application of finite element analysis in of clinical study of osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2016.08.027 |
| 中文关键词: 有限元分析 骨质疏松症；定量计算机断层扫描；临床研究 |
| 英文关键词:Finite element analysis Osteoporosis Quantitative computed tomography Clinical study |
| 基金项目: |
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| 中文摘要: |
| 为理清应用有限元分析（finite element analysis，FEA)进行临床研究的思路。本文就FEA在骨质疏松症床研究方法的进展、近年来临床研究中的成果、存在的主要问题进行综述。FEA是一种用于结构应力分析的技术，是日益普及的计算技术，是一个在机械性能预测领域潜力巨大的无损性工具,有可能成为黄金标准作为一种骨骼强度研究的替代方法。定量计算机 断层扫描（quantitative computed tomography,QCT)、HR-pQCT、micro-CT、三维成像软件等图像已经用于FEA建模。FEA在模拟各种骨质疏松状态下进行的实验研究已取得相当成果，同时不断在临床研究中得以应用。随着FEA技术的发展，使用FEA 进行较大样本、随机、多中心的临床研究已经成为可能，针对多种药物的临床疗效评估已经通过该方法得到证实。同时也可以将FEA运用于骨质疏松骨折风险的临床评估，可以准确地预测椎体抗压强度。FEA对骨质疏松症的骨折风险和药物治疗效果的评估是有用的，但是因为模型仍然敏感于扫描设定条件，从而限制了其结果的准确性和临床效果。如果临床成像技术能够在体内得到高清晰度图像，FEA将在其他可能改变骨骼结构和生物力学特性的疾病研究领域发挥重要作用。 |
| 英文摘要: |
| To enhance the application of Finite element analysis (FEA) in clinical studies, we reviewed recent progress of using FEA in clinical study of osteoporosis, the achievements and the associated problems. FEA is a technique for the analysis of structure, which is a computer technology with growing popularity, and a non-destructive tool in the prediction of mechanical behavior with powerful potential. FEA may become the gold standard as an alternative method to assess of bone strength. QCT, HR-pQCT, micro-CT, three-dimensional imaging software image have been used for FEA modeling. FEA simulation experimental studies have made considerable achievements, and had been applied in a variety of states of osteoporosis in clinical studies. With the development of FEA technology, it is possible to conduct large, randomized, multi-center clinical study. This method had been used to assess the efficacy of a variety of drugs. We can apply FEA to assess fracture risk, and to accurately predict compressive strength of the vertebral body. FEA is useful for fracture risk assessment and evaluating the effects of drug treatment on osteoporosis. However the accuracy and clinical effectiveness of FEA results are limited by its sensitivity to the scan setting conditions. If the clinical imaging techniques can obtain high-resolution images of the body, FEA will play more important roles in the studies of other diseases which are related to changes in bone structure and biomechanical properties. |
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