| Oxidative stress may play an important role in the pathogenesis of postmenopausal osteoporosis. After menopause, the body is affected by a combination of factors, including aging, estrogen deficiency, etc.，which increases the level of oxidative stress in the body. Oxidative stress can cause bone remodeling imbalance, and eventually can lead to osteoporosis. Of these, aging, estrogen deficiency, FoxO transcription factor and Nox subtype all have a close relationship with the production of reactive oxygen species and the pathogenesis of osteoporosis. In recent years, a number of studies investigated the pathogenesis of osteoporosis induced by oxidative stress, and progress has been made. By reviewing international and domestic literatures, this article summarizes the research progress on the pathogenesis of osteoporosis induced by oxidative stress. We also summarized the related factors and mechanisms of oxidative stress in the pathogenesis postmenopausal osteoporosis, and put forward some thoughts on the current research status and the perspectives of using antioxidant in the treatment of osteoporosis. |