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| 甲状旁腺激素通过增加血管及骨的形成防治骨质疏松 |
| Parathyroid hormone (1-34) prevents and treats osteoporosis by stimulation of angiogenesis andosteogenesis |
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| DOI： |
| 中文关键词: 去势大鼠，骨质疏松症，甲状旁腺激素，血管形成 |
| 英文关键词:OVX rats,Osteoporosis,Parathyroid hormone,Angiogenesis． |
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| 中文摘要: |
| 目的 探索甲状旁腺激素(PTH)对去势大鼠骨质疏松的防治作用。方法 30 只健康雌性 SD 大鼠随机行假手术(Sham，N =10)和双侧卵巢(OVX，N =20)切除手术后，所有 OVX 组大鼠随机的分成 2 组:OVX 组、PTH + OVX 组。术后第一天开始给予药物治疗，PTH + OVX 组:PTH 皮下注射(剂量 60 μg/kg，每周 3 次)，直至手术后 12 周为止，实验截止时间之前所有大鼠注射碘海醇后处死取股骨行 Micro-CT 检测。结果 与 OVX 组比较，PTH + OVX 组股骨远端有较高的 BMD、BV/TV、
Tb． Th、Tb． N、Conn． D、血管体积分数和较低的 Tb． Sp，其中 Sham 组大鼠股骨远端有最高的 BMD、BV/TV、Tb． Th、Tb． N、Conn．
D、血管体积分数和最低 Tb． Sp。结论 甲状旁腺激素通过促进血管形成及骨量增加来防治去势大鼠骨质疏松。 |
| 英文摘要: |
| Objective To investigate the effect of parathyroid hormone (1-34) on the prevention and treatment of osteoporosis inOVX rats． Methods After bilateral ovariectomy (OVX，n = 20) and sham operation (Sham，n = 10)，all animals from OVX
group were randomly divided into two groups，OVX group and PTH + OVX group． Ｒats in PTH + OVX group received PTH (60μg/kg，3 times a week) for 12 weeks． The rats were injected iohexol to observe angiogenesis before sacrificed． The distal femurs
were evaluated using micro-computerized tomography． Ｒesults Comparing with OVX group，the femurs in Sham and PTH +OVX groups had a higher BMD，BV/TV，Tb． Th，Tb． N，Conn． D，and vascular volume fraction，but a lower Tb． Sp． Ｒats in
Sham group had the highest BMD，BV/TV，Tb． Th，Tb． N，Conn． D，and vascular volume fraction，and the lowest Tb． Sp．Conclusion Parathyroid hormone (1-34) prevents and treats osteoporosis through enhanced angiogenesis and osteogenesis． |
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