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| 补肾活血药对绝经后骨质疏松妇女血清骨代谢因子的调控作用 |
| The effect of kidney-tonifying and activating-blood herb on the serum bone metabolic factors inpostmenopausal women with osteoporosis |
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| DOI： |
| 中文关键词: 中医中药 补肾活血中药 绝经后骨质疏松症 骨代谢因子 |
| 英文关键词:Traditional Chinese medicine Kidney-tonifying and activating-blood herb Postmenopausal osteoporosis Bone |
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| 中文摘要: |
| 观察补肾活血中药对绝经后骨质疏松妇女血清骨代谢因子的调控作用。方法 选择 2012 年 7 月 ～2013 年 12 月到广州市天河社区卫生院和广州中医药大学第一附属医院骨科门诊就诊的绝经后骨质疏松症患者共110 例，所有患者均以钙尔奇 D(600mg/日)作为基础药，将试验组(补肾活血中药 +钙尔奇 D)55 例与对照组(钙尔奇 D)55 例进行比较研究。临床疗效评估指标包括 VAS 疼痛评分、不良反应、双能 X 线骨密度仪检测腰椎和股骨颈骨密度(BMD)、酶联免疫吸附法(ELISA)检测服用补肾活血中药治疗前后血清 OPN 浓度，电化学发光免疫分析法(ECLIA)检测血清 25(OH)D、PINP 和 β-CTX 的浓度。结果 ①
VAS 疼痛评分:与治疗前相比，试验组 VAS 评分明显下降(P ＜0. 01);对照组有一定程度降低，但无统计学意义(P ＞0. 05)。②腰椎、左侧股骨颈的 BMD:与治疗前相比，试验组腰椎、左侧股骨颈的 BMD 治疗后显著增加(P ＜0. 05)，对照组治疗前后比较均无显著性差异。③血清 OPN、25(OH)D、PINP 和 β-CTX 指标:与治疗前相比，试验组 OPN、PINP 和 β-CTX 浓度治疗后明显下降(均为 P ＜0. 05)，25(OH)D 浓度治疗后明显升高(P ＜0. 05)，对照组治疗前后各项指标间比较均无显著性差异。试验过程中，两组间均未见严重不良反应发生。结论 补肾活血中药可缓解绝经后骨质疏松症患者疼痛症状，安全有效.它提高腰椎和股骨颈BMD 的作用可能是通过降低血清 OPN、PINP 和 β-CTX 浓度，提高25(OH)D 水平实现的. |
| 英文摘要: |
| Objective To evaluate the effect of a kidney-tonifying and activating-blood herb on the serum bone metabolic factors in women postmenopausal with osteoporosis． Methods A total of 110 postmenopausal women with osteoporosis who were in the outpatient of Community Health Center of the Forward Street of Tianhe district of Guangzhou and the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine from July 2012 to December 2013，were evaluated． All the patients received Caltrate D (600mg/day) as a basic medication． Patients in the experimental group (kidney-tonifying and activating-blood herb + Caltrate D，n =55) and in the control group (Caltrate D，n = 55) were compared． The methods to evaluate the clinical efficacy included the VAS pain scale，adverse reaction，BMD of the lumbar spine and the femoral neck measured by DXA，the serum level of OPN measured by enzyme-linked immunosorbent assay (ELISA)，and serum levels of 25(OH)D，PINP，and β-CTX measured by electrochemiluminescence immunoassay (ECLIA)． Ｒesults (1) VAS scale: The VAS scale decreased significantly in the experiment group after the treatment compared to that before the treatment (P ＜ 0. 01)． It decreased in the control group with no statistical significance． (2) BMD of the lumbar spine and femoral neck increased significantly in the experiment group after the Published online www． wanfangdate． com． cn doi:10. 3969/j． issn． 1006-7108. 2016. 09. 011 treatment compared to that before the treatment (P ＜ 0. 01)． No significant difference was found in control group between pre-treatment and post-treatment． (3) Serum levels of OPN，25(OH)D，PINP，and β-CTX decreased，but serum 25(OH)D level increased significantly，in the experiment group after the treatment compared to those before the treatment ( P ＜ 0. 01)． No significant difference was found in control group between pre-treatment and post-treatment． In the process of clinic test，there was no serious adverse reaction in both groups． Conclusion Kidney-tonifying and activating-blood herb relieves pain in post menopausal women with osteoporosis． It is safe and effective． The increase of BMD of the lumbar spine and the femoral neck may be through the decrease of the serum levels of OPN，PINP，and β-CTX，and the increase of serum 25(OH)D． |
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