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| 联合使用甲状旁腺激素和钙剂对骨质疏松的防治有叠加作用 |
| Combined treatment with parathyroid hormone (1-34) and calcium has an additive effect on the prevention and treatment of osteoporosis |
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| DOI： |
| 中文关键词: 去势大鼠 骨质疏松症 甲状旁腺激素 钙剂 |
| 英文关键词:OVX rats Parathyroid hormone Osteoporosis Calcium |
| 基金项目: |
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| 中文摘要: |
| 目的 探索联合使用甲状旁腺激素和钙剂对去势大鼠诱导骨质疏松的防治作用。方法 50 只健康雌性 SD 大鼠随机行假手术(Sham，N =10)和切除双侧卵巢(OVX，N =40)手术后，OVX 大鼠随机的分成 4 组:OVX 组、CA 组、PTH 组、PTH +CA 组。术后第一天 PTH 组及 PTH + CA 开始给予药物治疗:PTH 皮下注射(剂量 60 μg/kg，每周 3 次)。术后 CA 组及 PTH +CA 组大鼠饮食中加入钙剂，其余组大鼠普通饮食，直至手术后 12 周为止，12 时所有大鼠处死取胫骨行 Micro-CT、硬组织切片检测。结果 CA 组、PTH 组、PTH + CA 组和 OVX 组相比，胫骨近端都有较高的 BMD、BV/TV、Tb． Th、Tb． N、Conn． D、骨矿化沉积率(MAＲ)和较低的 Tb． Sp，其中 PTH + CA 组大鼠胫骨有最高的 BMD、BV/TV、Tb． Th、Tb． N、Conn． D、MAＲ 和最低 Tb． Sp。钙剂和 PTH 单独使用的效果明显低于他们联合使用对去卵巢大鼠骨质疏松的防治作用。结论 联合使用甲状旁腺激素和钙剂对去势大鼠骨质疏松的防治有叠加作用 |
| 英文摘要: |
| Objective To investigate the effect of combined treatment with calcium and PTH on the prevention and treatment of osteoporosis in OVX rats． Methods After bilateral ovariectomy (OVX，n =40) and Sham-operation (Sham，n =10)，all animals from OVX group were randomly divided into 4 groups，group OVX，group CA，group PTH，and group PTH + CA． Ｒats in group PTH and PTH + CA received PTH (60 μg/kg，3 times a week)，and in group CA and PTH + CA received high calcium diet for 12 weeks． The proximal tibias of rats were harvested and were evaluated using micro-computerized tomography and undecalcified
slices． Ｒesults Comparison with group OVX，the tibia in group CA，PTH，and PTH + CA had a higher BMD，BV/TV，Tb． Th， Tb． N，Conn． D，and bone mineral apposition rate，but a lower Tb． Sp． Ｒats in group PTH + CA had the highest BV/TV，Tb． Th， Tb． N，Conn． D，BMD，bone mineral apposition rate，and the lowest Tb． Sp． The effect of PTH or calcium using alone is significantly lower than their combined use for prevention and treatment of osteoporosis in OVX rats． Conclusion PTH combined with calcium has an additive effect on osteoporosis in OVX rats． |
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