中国骨质疏松杂志

2 型糖尿病性骨质疏松的鼠类模型的研究进展

Ｒesearch progress in the rodent model of type 2 diabetic osteoporosis

DOI：

英文关键词:Type 2 diabetes Osteoporosis Animal model Bone metabolism Bone structure Bone mineral density

基金项目:

作者	单位
梁燕龙 1，2 杜敏群 1，2 赖文秀 1，2 李淑惠 1，2 崔燎 1，2*	1．广东医学院药理学教研室，广东湛江 524023 2．广东医学院广东天然药物研究与开发重点实验室，广东湛江 524023

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中文摘要:

2 型糖尿病性骨质疏松(Type 2 Diabetic Osteoporosis，T2DOP)的病因复杂，对治疗带来困难，因此，建立符合人类 2 型糖尿病发病特点、骨代谢和骨结构的动物模型在 T2DOP 发病机制及其防治研究中的意义重大。由于鼠类的骨结构特点与人类相似，而且容易繁殖，目前国内外 T2DOP 动物模型研究也大多数在鼠类的研究。国内采用诱发性鼠类模型观察到其骨代谢和骨结构异常报道居多，国内外观察自发性 2 型糖尿病鼠类模型和转基因/基因敲除 2 型糖尿病鼠类模型的骨代谢和骨结构也存在异常，但是尚无一种既能在其骨骼成熟后发展为 2 型糖尿病，又能协同多基因和环境因素的 2 型糖尿病鼠类模型。故本文对研究的 T2DOP 鼠类模型的构建、骨代谢特征及其骨结构做一综述，为建立更为完善的 2 型糖尿病模型，进一步推动 2 型糖尿病性骨质疏松的机制研究和药物研发。

英文摘要:

The complicated etiology of type 2 diabetic osteoporosis (T2DOP) brings difficulties for treatment． Therefore，it is important to establish animal models which fit the feature of human type 2 diabetes，bone metabolism，and bone structure for study of the mechanism and prevention of T2DOP． Since the bone structure in rodent is similar to that in humans and the rodent is easy in propagation，the most studies both at home and abroad for the animal model of T2DOP tend to study in rodent model at presont． More and more national literatures report the abnormal bone metabolism and structure in the experimental type 2 diabetic rodent model． The abnormal bone metabolism and structure are also found in in spontaneous type 2 diabetic rodent model and gene knockout type 2 diabetic rodent model． However，there is no single type 2 diabetic rodent model that not only spontaneously develops diabetes after skeletal maturity，but also combines multiple genes and environmental factors． This paper reviews the establishment，bone metabolism，and bone structure of the T2DOP animal model，in order to build a more perfect model of type 2 diabetes，and to further promote the development of pathogenesis research and drug research for T2DOP．

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