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| miＲ 对骨质疏松骨代谢信号通路影响的研究进展 |
| The research progress of the effect of miＲ on bone metabolism signal pathway in osteoporosis |
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| DOI： |
| 中文关键词: miＲ 信号通路 骨代谢 骨质疏松 |
| 英文关键词:miＲ Signal pathway Bone metabolism Osteoporosis |
| 基金项目: |
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| 中文摘要: |
| miＲ 在骨骼发育、代谢过程中具有重要的生物学功能，能够调控骨细胞生长、分化和功能表达。正常机体中，骨代谢相关信号通路对维持骨骼正常生物学功能意义重大，miＲ 通过与骨代谢相关的多种信号通路调节成骨细胞/破骨细胞代谢，达到有利于机体的平衡状态，如果 miＲ 表达失调这种稳态就会失衡，相关信号通路被激活，导致相应的骨代谢疾病，如骨质疏松症。信号通路作为调控骨代谢的重要途径，不同信号通路机制之间存在一定的联系，但是大多数信号通路的确切机制还不明了，各通路之间的相互联系研究较少，随着表观遗传学的发展，miＲ 通过相关信号通路精密调控骨代谢的机制被逐步阐明。miＲ 与多种骨质疏松多种信号通路存在密切的关系，成为潜在的检测标志物和治疗靶向点。研究 miＲ 参与调控骨质疏松骨代谢相关信号通路的机制，在骨质疏松的预防、诊治及预后意义重大。本文将从三个方面对近年来 miＲ 对骨质疏松症骨代谢相关信号通路的研究作以概述。 |
| 英文摘要: |
| miＲ plays an important biological role in skeletal development and metabolism． It regulates bone cell growth，differentiation，and functional expression． In the normal body，the signal pathway of bone metabolism is of great significance to the maintenance of normal biological function of the bone． miＲ regulates osteoblast/osteoblast metabolism through various signal
pathways related to bone metabolism，which is beneficial to the balance of the body． If the of miＲ expression is imbalance，the related signal pathway is activated，leading to the corresponding bone metabolic diseases such as osteoporosis． Signal pathway is a important way of regulating bone metabolism． There are certain connections between different signal pathways． However，mechanism related to signal pathway is unclear and the related research is few． The mechanism of miＲ related signal pathways of precise control of bone metabolism has been gradually elucidated with the development of epigenetics． miＲ is closely related to a variety of osteoporosis signal pathways． It has become a potential detection markers and a therapeutic target． It is of great significance of the study the mechanism of miＲ-involved regulation of bone metabolism and related signaling pathways，and the
prevention，diagnosis，and treatment of osteoporosis． This paper summarizes the research of miＲ in bone metabolism related signal pathway in osteoporosis in recent years from three aspects． |
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